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Preclinical evaluation of new α-radionuclide therapy targeting LAT1: 2-[211At]astato-α-methyl-L-phenylalanine in tumor-bearing model
https://repo.qst.go.jp/records/85578
https://repo.qst.go.jp/records/85578349ffd64-534d-4f78-921f-3ebf613d2d9e
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-07 | |||||
| タイトル | ||||||
| タイトル | Preclinical evaluation of new α-radionuclide therapy targeting LAT1: 2-[211At]astato-α-methyl-L-phenylalanine in tumor-bearing model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yasuhiro, Oshima
× Yasuhiro, Oshima× Hiroyuki, Suzuki× Hirofumi, Hanaoka× Ichiro, Sasaki× Shigeki, Watanabe× Hiromitsu, Haba× Yasushi, Arano× Yoshito, Tsushima× Noriko, Ishioka× Yasuhiro, Oshima× Ichiro, Sasaki× Shigeki, Watanabe× Noriko, Ishioka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Targeted α-radionuclide therapy has attracted attention as a promising therapy for refractory cancers. However, the application is limited to certain types of cancer. Since L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers, radiopharmaceuticals targeting LAT1 would enable the wider use of targeted α-therapy. We previously developed fluorine-18 (18F)- or bromine-76 (76Br)-labeled amino acid tracers targeting LAT1. Among them, 2-[18F]- or 2-[76Br]-labeled α-methyl-L-phenylalanine analog was specifically taken up by tumor via LAT1, while they were rapidly cleared from body and excreted into urine. Since 18F and 76Br belong to radiohalogen, astatine-211 (211At), an α-emitting halogen, labeled α-methyl-L-phenylalanine is expected to show high tumor accumulation and preferred pharmacokinetics. In this study, we newly synthesized 2-[211At]astato-α-methyl-L-phenylalanine (2-[211At]AAMP), and evaluated its potential as a therapeutic agent. | |||||
| 書誌情報 |
QST Takasaki Annual Report 2020 p. 90-90, 発行日 2022-03 |
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| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.qst.go.jp/site/taka/2106.html | |||||
