{"created":"2023-05-15T15:03:10.500370+00:00","id":85578,"links":{},"metadata":{"_buckets":{"deposit":"4dd53d69-ba8d-451a-a5e1-2e522578c561"},"_deposit":{"created_by":1,"id":"85578","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85578"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085578","sets":["7"]},"author_link":["1033285","1033283","1033288","1033287","1033291","1033286","1033284","1033292","1033294","1033290","1033293","1033289","1033295"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"90","bibliographicPageStart":"90","bibliographic_titles":[{"bibliographic_title":"QST Takasaki Annual Report 2020"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Targeted α-radionuclide therapy has attracted attention as a promising therapy for refractory cancers. However, the application is limited to certain types of cancer. Since L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers, radiopharmaceuticals targeting LAT1 would enable the wider use of targeted α-therapy. We previously developed fluorine-18 (18F)- or bromine-76 (76Br)-labeled amino acid tracers targeting LAT1. Among them, 2-[18F]- or 2-[76Br]-labeled α-methyl-L-phenylalanine analog was specifically taken up by tumor via LAT1, while they were rapidly cleared from body and excreted into urine. Since 18F and 76Br belong to radiohalogen, astatine-211 (211At), an α-emitting halogen, labeled α-methyl-L-phenylalanine is expected to show high tumor accumulation and preferred pharmacokinetics. In this study, we newly synthesized 2-[211At]astato-α-methyl-L-phenylalanine (2-[211At]AAMP), and evaluated its potential as a therapeutic agent.","subitem_description_type":"Abstract"}]},"item_10004_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.qst.go.jp/site/taka/2106.html","subitem_relation_type_select":"URI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yasuhiro, Oshima"}],"nameIdentifiers":[{"nameIdentifier":"1033283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroyuki, Suzuki"}],"nameIdentifiers":[{"nameIdentifier":"1033284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirofumi, Hanaoka"}],"nameIdentifiers":[{"nameIdentifier":"1033285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichiro, Sasaki"}],"nameIdentifiers":[{"nameIdentifier":"1033286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeki, Watanabe"}],"nameIdentifiers":[{"nameIdentifier":"1033287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiromitsu, Haba"}],"nameIdentifiers":[{"nameIdentifier":"1033288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasushi, Arano"}],"nameIdentifiers":[{"nameIdentifier":"1033289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshito, Tsushima"}],"nameIdentifiers":[{"nameIdentifier":"1033290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriko, Ishioka"}],"nameIdentifiers":[{"nameIdentifier":"1033291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuhiro, Oshima","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1033292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichiro, Sasaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1033293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeki, Watanabe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1033294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriko, Ishioka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1033295","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Preclinical evaluation of new α-radionuclide therapy targeting LAT1: 2-[211At]astato-α-methyl-L-phenylalanine in tumor-bearing model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Preclinical evaluation of new α-radionuclide therapy targeting LAT1: 2-[211At]astato-α-methyl-L-phenylalanine in tumor-bearing model"}]},"item_type_id":"10004","owner":"1","path":["7"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-07"},"publish_date":"2021-10-07","publish_status":"0","recid":"85578","relation_version_is_last":true,"title":["Preclinical evaluation of new α-radionuclide therapy targeting LAT1: 2-[211At]astato-α-methyl-L-phenylalanine in tumor-bearing model"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:36:46.070436+00:00"}