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Preliminery examination of soft agar colony formation assay for PC12 pheochromocytoma cells
https://repo.qst.go.jp/records/85521
https://repo.qst.go.jp/records/85521f370adc1-0c83-4539-8a5f-cb33999aad9a
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-03-14 | |||||
| タイトル | ||||||
| タイトル | Preliminery examination of soft agar colony formation assay for PC12 pheochromocytoma cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tetsuya, Sakashita
× Tetsuya, Sakashita× Yasuhiro, Oshima× Yuuichiro, Yokota× Noriko, Ishioka× Tetsuya, Sakashita× Yasuhiro, Oshima× Yuuichiro, Yokota× Noriko, Ishioka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We reported strong anti-tumor effects of α-emitting meta-211At-astato-benzylguanidine (211At-MABG) in a PCC mouse model, suggesting a potential option for targeted α therapy (TAT) for patients with malignant PCC. We also found that the gene expression profiles of cell cycle checkpoints displayed similar modes of cell death via the p53-p21 signaling pathway after 211At-MABG treatment and -ray irradiation. This p53-dependent pathway would induce reproductive cell death, e.g. cell cycle arrest. However, we have not yet checked for reproductive cell death in PCC (PC12) cells by colony formation assays because PC12 cells showed strong aggregation. Here, we preliminary reported the surviving fraction of -ray irradiated PC12 cells using the soft-agar colony formation assay. | |||||
| 書誌情報 |
QST Takasaki Annual Report 2020 p. 89, 発行日 2022-03 |
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