@article{oai:repo.qst.go.jp:00085521,
 author = {Tetsuya, Sakashita and Yasuhiro, Oshima and Yuuichiro, Yokota and Noriko, Ishioka and Tetsuya, Sakashita and Yasuhiro, Oshima and Yuuichiro, Yokota and Noriko, Ishioka},
 journal = {QST Takasaki Annual Report 2020},
 month = {Mar},
 note = {We reported strong anti-tumor effects of α-emitting meta-211At-astato-benzylguanidine (211At-MABG) in a PCC mouse model, suggesting a potential option for targeted α therapy (TAT) for patients with malignant PCC. We also found that the gene expression profiles of cell cycle checkpoints displayed similar modes of cell death via the p53-p21 signaling pathway after 211At-MABG treatment and -ray irradiation. This p53-dependent pathway would induce reproductive cell death, e.g. cell cycle arrest. However, we have not yet checked for reproductive cell death in PCC (PC12) cells by colony formation assays because PC12 cells showed strong aggregation.  Here, we preliminary reported the surviving fraction of -ray irradiated PC12 cells using the soft-agar colony formation assay.},
 title = {Preliminery examination of soft agar colony formation assay for PC12 pheochromocytoma cells},
 year = {2022}
}