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Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system
https://repo.qst.go.jp/records/85382
https://repo.qst.go.jp/records/85382e149d6b6-3bf6-4666-9668-0ae1b4bfbdef
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-11-24 | |||||
| タイトル | ||||||
| タイトル | Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kazuho, Kojima
× Kazuho, Kojima× Shigeki, Hirano× Yasuyuki, Kimura× Chie, Seki× Yoko, Ikoma× Keisuke, Takahata× Takehito, Ito× Keita, Yokokawa× Hiroki, Hashimoto× Kazunori, Kawamura× Zhang, Ming-Rong× Ito, Hiroshi× Makoto, Higuchi× Kuwabara, Satoshi× Tetsuya, Suhara× Makiko, Yamada× Kazuho, Kojima× Shigeki, Hirano× Yasuyuki, Kimura× Chie, Seki× Yoko, Ikoma× Keisuke, Takahata× Takehito, Ito× Keita, Yokokawa× Hiroki, Hashimoto× Kazunori, Kawamura× Zhang, Ming-Rong× Makoto, Higuchi× Tetsuya, Suhara× Makiko, Yamada |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Rationale The tendency to avoid punishment, called behavioral inhibition system, is an essential aspect of motivational behavior. Behavioral inhibition system is related to negative affect, such as anxiety, depression and pain, but its neural basis has not yet been clarified. Objectives To clarify the association between individual variations in behavioral inhibition system and brain 5-HT2A receptor availability and specify which brain networks were involved in healthy male subjects, using [18F]altanserin positron emission tomography and resting-state functional magnetic resonance imaging. Results Behavioral inhibition system score negatively correlated with 5-HT2A receptor availability in anterior cingulate cortex. A statistical model indicated that the behavioral inhibition system score was associated with 5-HT2A receptor availability, which was mediated by the functional connectivity between anterior cingulate cortex and left middle frontal gyrus, both of which involved in the cognitive control of negative information processing. Conclusions Individuals with high behavioral inhibition system displays low 5-HT2A receptor availability in anterior cingulate cortex and this cognitive control network links with prefrontal-cingulate integrity. These findings have implications for underlying the serotonergic basis of physiologies in aversion. | |||||
| 書誌情報 |
Brain Imaging and Behavior 巻 16, p. 1337-1348, 発行日 2022-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1931-7557 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35006540 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s11682-021-00609-2 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://link.springer.com/article/10.1007/s11682-021-00609-2 | |||||
