@article{oai:repo.qst.go.jp:00085382,
 author = {Kazuho, Kojima and Shigeki, Hirano and Yasuyuki, Kimura and Chie, Seki and Yoko, Ikoma and Keisuke, Takahata and Takehito, Ito and Keita, Yokokawa and Hiroki, Hashimoto and Kazunori, Kawamura and Zhang, Ming-Rong and Ito, Hiroshi and Makoto, Higuchi and Kuwabara, Satoshi and Tetsuya, Suhara and Makiko, Yamada and Kazuho, Kojima and Shigeki, Hirano and Yasuyuki, Kimura and Chie, Seki and Yoko, Ikoma and Keisuke, Takahata and Takehito, Ito and Keita, Yokokawa and Hiroki, Hashimoto and Kazunori, Kawamura and Zhang, Ming-Rong and Makoto, Higuchi and Tetsuya, Suhara and Makiko, Yamada},
 journal = {Brain Imaging and Behavior},
 month = {Jan},
 note = {Rationale The tendency to avoid punishment, called behavioral inhibition system, is an essential aspect of motivational behavior. Behavioral inhibition system is related to negative affect, such as anxiety, depression and pain, but its neural basis has not yet been clarified. Objectives To clarify the association between individual variations in behavioral inhibition system and brain 5-HT2A receptor availability and specify which brain networks were involved in healthy male subjects, using [18F]altanserin positron emission tomography and resting-state functional magnetic resonance imaging. Results Behavioral inhibition system score negatively correlated with 5-HT2A receptor availability in anterior cingulate cortex. A statistical model indicated that the behavioral inhibition system score was associated with 5-HT2A receptor availability, which was mediated by the functional connectivity between anterior cingulate cortex and left middle frontal gyrus, both of which involved in the cognitive control of negative information processing. Conclusions Individuals with high behavioral inhibition system displays low 5-HT2A receptor availability in anterior cingulate cortex and this cognitive control network links with prefrontal-cingulate integrity. These findings have implications for underlying the serotonergic basis of physiologies in aversion.},
 pages = {1337--1348},
 title = {Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system},
 volume = {16},
 year = {2022}
}