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Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model
https://repo.qst.go.jp/records/85381
https://repo.qst.go.jp/records/8538142403d88-313b-41f1-8739-7c5338bcd2cb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-12-08 | |||||
| タイトル | ||||||
| タイトル | Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sato, Hideaki
× Sato, Hideaki× Takado, Yuhei× Toyoda, Sakiko× Masako, Tsukamoto-Yasui× Minatohara, Keiichiro× Takuwa, Hiroyuki× Urushihata, Takuya× Takahashi, Manami× Shimojo, Masafumi× Ono, Maiko× Maeda, Jun× Orihara, Asumi× Sahara, Naruhiko× Aoki, Ichio× Karakawa, Sachise× Isokawa, Muneki× Kawasaki, Noriko× Kawasaki, Mika× Ueno, Satoko× Kanda, Mayuka× Nishimura, Mai× Suzuki, Katsuya× Mitsui, Akira× Nagao, Kenji× Kitamura, Akihiko× Higuchi, Makoto× Sato, Hideaki× Yuhei, Takado× Keiichiro, Minatohara× Hiroyuki, Takuwa× Takuya, Urushihata× Takahashi, Manami× Masafumi, Shimojo× Maiko, Ono× Jun, Maeda× Asumi, Orihara× Naruhiko, Sahara× Ichio, Aoki× Akihiko, Kitamura× Makoto, Higuchi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Protein malnutrition is epidemiologically suggested as a potential risk factor for senile dementia, although molecular mechanisms linking dietary proteins and amino acids to neurodegeneration remain unknown. Here, we show that a low-protein diet resulted in down-regulated expression of synaptic components and a modest acceleration of brain atrophy in mice modeling neurodegenerative tauopathies. Notably, these abnormal phenotypes were robustly rescued by the administration of seven selected essential amino acids. The up-regulation of inflammation-associated gene expression and progressive brain atrophy in the tauopathy model were profoundly suppressed by treatment with these essential amino acids without modifications of tau depositions. Moreover, the levels of kynurenine, an initiator of a pathway inducing neuroinflammatory gliosis and neurotoxicity in the brain, were lowered by treatment through inhibition of kynurenine uptake in the brain. Our findings highlight the importance of specific amino acids as systemic mediators of brain homeostasis against neurodegenerative processes. | |||||
| 書誌情報 |
Science advances 巻 7, 号 43, p. eabd5046, 発行日 2021-10 |
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| 出版者 | ||||||
| 出版者 | AAAS | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2375-2548 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34678069 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1126/sciadv.abd5046 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.science.org/doi/10.1126/sciadv.abd5046 | |||||
