@article{oai:repo.qst.go.jp:00085381,
 author = {Sato, Hideaki and Takado, Yuhei and Toyoda, Sakiko and Masako, Tsukamoto-Yasui and Minatohara, Keiichiro and Takuwa, Hiroyuki and Urushihata, Takuya and Takahashi, Manami and Shimojo, Masafumi and Ono, Maiko and Maeda, Jun and Orihara, Asumi and Sahara, Naruhiko and Aoki, Ichio and Karakawa, Sachise and Isokawa, Muneki and Kawasaki, Noriko and Kawasaki, Mika and Ueno, Satoko and Kanda, Mayuka and Nishimura, Mai and Suzuki, Katsuya and Mitsui, Akira and Nagao, Kenji and Kitamura, Akihiko and Higuchi, Makoto and Sato, Hideaki and Yuhei, Takado and Keiichiro, Minatohara and Hiroyuki, Takuwa and Takuya, Urushihata and Takahashi, Manami and Masafumi, Shimojo and Maiko, Ono and Jun, Maeda and Asumi, Orihara and Naruhiko, Sahara and Ichio, Aoki and Akihiko, Kitamura and Makoto, Higuchi},
 issue = {43},
 journal = {Science advances},
 month = {Oct},
 note = {Protein malnutrition is epidemiologically suggested as a potential risk factor for senile dementia, although molecular mechanisms linking dietary proteins and amino acids to neurodegeneration remain unknown. Here, we show that a low-protein diet resulted in down-regulated expression of synaptic components and a modest acceleration of brain atrophy in mice modeling neurodegenerative tauopathies. Notably, these abnormal phenotypes were robustly rescued by the administration of seven selected essential amino acids. The up-regulation of inflammation-associated gene expression and progressive brain atrophy in the tauopathy model were profoundly suppressed by treatment with these essential amino acids without modifications of tau depositions. Moreover, the levels of kynurenine, an initiator of a pathway inducing neuroinflammatory gliosis and neurotoxicity in the brain, were lowered by treatment through inhibition of kynurenine uptake in the brain. Our findings highlight the importance of specific amino acids as systemic mediators of brain homeostasis against neurodegenerative processes.},
 title = {Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model},
 volume = {7},
 year = {2021}
}