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Effects of loading a magnetic field longitudinal to the linear particle-beam track on yields of reactive oxygen species in water
https://repo.qst.go.jp/records/85288
https://repo.qst.go.jp/records/8528800b3496e-cd08-403c-92bb-b41096d8629f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Matsumoto.K.2021.Free.Radic.Res.55(5).547-555.Full_version.magnetic_field.carbon-ion.ROS.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-12-04 | |||||
| タイトル | ||||||
| タイトル | Effects of loading a magnetic field longitudinal to the linear particle-beam track on yields of reactive oxygen species in water | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× Nakanishi, Ikuo× Abe, Yasushi× Sato, Shinji× Muramatsu, Masayuki× Kohno, Ryosuke× Sakata, Dousatsu× Mizushima, Kota× Sung-Hyun, Lee× Sakama, Makoto× Inaniwa, Taku× Kenichiro, Matsumoto× Ikuo, Nakanishi× Yasushi, Abe× Shinji, Sato× Masayuki, Muramatsu× Ryosuke, Kohno× Dousatsu, Sakata× Kota, Mizushima× Sung-Hyun, Lee× Makoto, Sakama× Taku, Inaniwa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of a magnetic field longitudinal to the ion beam track on the generation of hydroxyl radicals (•OH) and hydrogen peroxide (H2O2) in water were investigated. A longitudinal magnetic field was reported to enhance the biological effects of the ion beam. However, the mechanism of the increased cell death by a longitudinal magnetic field has not been clarified. The local density of •OH generation was estimated by a method based on the EPR spin-trapping. A series of reaction mixtures containing varying concentrations (0.76‒2278 mM) of DMPO was irradiated by 16 Gy of carbon- or iron-ion beams at the Heavy-Ion Medical Accelerator in Chiba (HIMAC, NIRS/QST, Chiba, Japan) with or without a longitudinal magnetic field (0.0, 0.3, or 0.6 T). The DMPO-OH yield in the sample solutions was measured by X-band EPR and plotted versus DMPO density. O2-dependent and O2-independent H2O2 yields were measured. An aliquot of ultra-pure water was irradiated by carbon-ion beams with or without a longitudinal magnetic field. Irradiation experiments were performed under air or hypoxic conditions. H2O2 generation in irradiated water samples was quantified by an EPR spin-trapping, which measures •OH synthesized from H2O2 by UVB irradiation. Relatively sparse •OH generation caused by particle beams in water were not affected by loading a magnetic field on the beam track. O2-dependent H2O2 generation decreased and oxygen-independent H2O2 generation increased after loading a magnetic field parallel to the beam track. Loading a magnetic field to the beam track made •OH generation denser or made dense •OH more reactive. | |||||
| 書誌情報 |
Free Radical Research 巻 55, 号 5, p. 547-555, 発行日 2021-09 |
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| 出版者 | ||||||
| 出版者 | Taylor & Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1029-2470 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34569399 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/10715762.2021.1970151 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1080/10715762.2021.1970151 | |||||
