@article{oai:repo.qst.go.jp:00085288,
 author = {Ken-ichiro, Matsumoto and Nakanishi, Ikuo and Abe, Yasushi and Sato, Shinji and Muramatsu, Masayuki and Kohno, Ryosuke and Sakata, Dousatsu and Mizushima, Kota and Sung-Hyun, Lee and Sakama, Makoto and Inaniwa, Taku and Kenichiro, Matsumoto and Ikuo, Nakanishi and Yasushi, Abe and Shinji, Sato and Masayuki, Muramatsu and Ryosuke, Kohno and Dousatsu, Sakata and Kota, Mizushima and Sung-Hyun, Lee and Makoto, Sakama and Taku, Inaniwa},
 issue = {5},
 journal = {Free Radical Research},
 month = {Sep},
 note = {The effects of a magnetic field longitudinal to the ion beam track on the generation of hydroxyl radicals (•OH) and hydrogen peroxide (H2O2) in water were investigated. A longitudinal magnetic field was reported to enhance the biological effects of the ion beam. However, the mechanism of the increased cell death by a longitudinal magnetic field has not been clarified. The local density of •OH generation was estimated by a method based on the EPR spin-trapping. A series of reaction mixtures containing varying concentrations (0.76‒2278 mM) of DMPO was irradiated by 16 Gy of carbon- or iron-ion beams at the Heavy-Ion Medical Accelerator in Chiba (HIMAC, NIRS/QST, Chiba, Japan) with or without a longitudinal magnetic field (0.0, 0.3, or 0.6 T). The DMPO-OH yield in the sample solutions was measured by X-band EPR and plotted versus DMPO density. O2-dependent and O2-independent H2O2 yields were measured. An aliquot of ultra-pure water was irradiated by carbon-ion beams with or without a longitudinal magnetic field. Irradiation experiments were performed under air or hypoxic conditions. H2O2 generation in irradiated water samples was quantified by an EPR spin-trapping, which measures •OH synthesized from H2O2 by UVB irradiation. Relatively sparse •OH generation caused by particle beams in water were not affected by loading a magnetic field on the beam track. O2-dependent H2O2 generation decreased and oxygen-independent H2O2 generation increased after loading a magnetic field parallel to the beam track. Loading a magnetic field to the beam track made •OH generation denser or made dense •OH more reactive.},
 pages = {547--555},
 title = {Effects of loading a magnetic field longitudinal to the linear particle-beam track on yields of reactive oxygen species in water},
 volume = {55},
 year = {2021}
}