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Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging
https://repo.qst.go.jp/records/85035
https://repo.qst.go.jp/records/85035c1f5b578-df24-4962-a8ee-26f892d474b5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Matsumoto.K.2022.Antioxid.Redox.Signal.36(1-3).95-121.nitroxide.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2022-01-07 | |||||
| タイトル | ||||||
| タイトル | Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kenichiro, Matsumoto
× Kenichiro, Matsumoto× Nakanishi, Ikuo× Zhelev, Zhivko× Bakalova, Rumiana× Aoki, Ichio× Kenichiro, Matsumoto× Ikuo, Nakanishi× Bakalova, Rumiana× Ichio, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Significance: In vivo assessment of paramagnetic and diamagnetic conversions of nitroxyl radicals based on cyclic redox mechanism can be an index of tissue redox status. The redox mechanism of nitroxyl radicals, which enables their use as a normal tissue-selective radioprotector, is seen as being attractive on planning radiation therapy. Recent Advances: In vivo redox imaging using nitroxyl radicals as redox-sensitive contrast agents has been developed to assess tissue redox status. Chemical and biological behaviors depending on chemical structures of nitroxyl radical compounds have been understood in detail. Polymer types of nitroxyl radical contrast agents and/or nitroxyl radical-labeled drugs were designed for approaching theranostics. Critical Issues: Nitroxyl radicals as magnetic resonance imaging (MRI) contrast agents have several advantages compared with those used in electron paramagnetic resonance (EPR) imaging, while support by EPR spectroscopy is important to understand information from MRI. Redox-sensitive paramagnetic contrast agents having a medicinal benefit, that is, nitroxyl-labeled drug, have been developed and proposed. Future Directions: A development of suitable nitroxyl contrast agent for translational theranostic applications with high reaction specificity and low normal tissue toxicity is under progress. Nitroxyl radicals as redox-sensitive magnetic resonance contrast agents can be a useful tool to detect an abnormal tissue redox status such as disordered oxidative stress. | |||||
| 書誌情報 |
Antioxidants & Redox Signaling 巻 36, 号 1-3, p. 95-121, 発行日 2021-07 |
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| 出版者 | ||||||
| 出版者 | Mary Ann Liebert, Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1523-0864 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34148403 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1089/ars.2021.0110 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.liebertpub.com/doi/10.1089/ars.2021.0110 | |||||
