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Hypoxia and Proton microbeams: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells
https://repo.qst.go.jp/records/85031
https://repo.qst.go.jp/records/85031f5aa124c-841a-4a38-8224-742f458fa68c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-05-15 | |||||
| タイトル | ||||||
| タイトル | Hypoxia and Proton microbeams: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Autsavapromporn, Narongchai
× Autsavapromporn, Narongchai× Kobayashi, Alisa× Liu, Cuihua× Jaikang, Churdsak× Ahbrizal Tengku Ahmad, Tengku× Oikawa, Masakazu× Konishi, Teruaki× Alisa, Kobayashi× Liu, Cuihua× Masakazu, Oikawa× Teruaki, Konishi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hypoxia plays an important role in the development of malignant solid tumor and is associated with therapeutic resistance and poor outcome treatment. This condition may be due to the ability of hypoxic cells to influence bystander response through gap junction intercellular communication (GJIC) that may reduce the effectiveness of radiation therapy (RT) and increase normal tissue toxicity. The present study is aimed to investigate the role of GJIC and hypoxia-induced bystander response in lung cancer (A549) and normal lung fibroblast (WI-38) under normoxia and hypoxia, when exposed to high LET (linear energy transfer) proton microbeams. The results of our study showed that for the first time there was a difference hypoxia-induced bystander response be-tween cancer and normal cells and GJIC plays a key role in the observed effects. | |||||
| 書誌情報 |
Radiation Research 巻 197, 号 2, p. 122-130, 発行日 2021-10 |
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| 出版者 | ||||||
| 出版者 | Radiation Research Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1667/RADE-21-00112.1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://meridian.allenpress.com/radiation-research/article/doi/10.1667/RADE-21-00112.1/471759/Hypoxia-and-Proton-microbeam-Role-of-Gap-Junction | |||||
