{"created":"2023-05-15T15:02:42.968258+00:00","id":85031,"links":{},"metadata":{"_buckets":{"deposit":"630c29c1-2152-44d1-aae5-2a848a7ea2b0"},"_deposit":{"created_by":1,"id":"85031","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85031"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085031","sets":["1"]},"author_link":["1034936","1034938","1034937","1034932","1034940","1034939","1034931","1034935","1034930","1034933","1034934"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"130","bibliographicPageStart":"122","bibliographicVolumeNumber":"197","bibliographic_titles":[{"bibliographic_title":"Radiation Research "}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hypoxia plays an important role in the development of malignant solid tumor and is associated with therapeutic resistance and poor outcome treatment. This condition may be due to the ability of hypoxic cells to influence bystander response through gap junction intercellular communication (GJIC) that may reduce the effectiveness of radiation therapy (RT) and increase normal tissue toxicity. The present study is aimed to investigate the role of GJIC and hypoxia-induced bystander response in lung cancer (A549) and normal lung fibroblast (WI-38) under normoxia and hypoxia, when exposed to high LET (linear energy transfer) proton microbeams. The results of our study showed that for the first time there was a difference hypoxia-induced bystander response  be-tween cancer and normal cells and GJIC plays a key role in the observed effects.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Radiation Research Society"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1667/RADE-21-00112.1","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://meridian.allenpress.com/radiation-research/article/doi/10.1667/RADE-21-00112.1/471759/Hypoxia-and-Proton-microbeam-Role-of-Gap-Junction","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Autsavapromporn, Narongchai"}],"nameIdentifiers":[{"nameIdentifier":"1034930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Alisa"}],"nameIdentifiers":[{"nameIdentifier":"1034931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liu, Cuihua"}],"nameIdentifiers":[{"nameIdentifier":"1034932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jaikang, Churdsak"}],"nameIdentifiers":[{"nameIdentifier":"1034933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ahbrizal Tengku Ahmad, Tengku"}],"nameIdentifiers":[{"nameIdentifier":"1034934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oikawa, Masakazu"}],"nameIdentifiers":[{"nameIdentifier":"1034935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki"}],"nameIdentifiers":[{"nameIdentifier":"1034936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Alisa, Kobayashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1034937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liu, Cuihua","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1034938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masakazu, Oikawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1034939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Teruaki, Konishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1034940","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hypoxia and Proton microbeams: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses  on Human Lung Cancer Cells and Normal Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hypoxia and Proton microbeams: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses  on Human Lung Cancer Cells and Normal Cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-05-15"},"publish_date":"2021-05-15","publish_status":"0","recid":"85031","relation_version_is_last":true,"title":["Hypoxia and Proton microbeams: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses  on Human Lung Cancer Cells and Normal Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:34:19.385209+00:00"}