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Development of an MRI contrast agent for both detection and inhibition of the amyloid-b fibrillation process
https://repo.qst.go.jp/records/85010
https://repo.qst.go.jp/records/85010997c3e50-e16d-4eba-85a4-da75889dc4a1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-02-24 | |||||
| タイトル | ||||||
| タイトル | Development of an MRI contrast agent for both detection and inhibition of the amyloid-b fibrillation process | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yudi Utomo, Rohmad
× Yudi Utomo, Rohmad× Okada, Satoshi× Akira, Sumiyoshi× Asawa, Yasunobu× Seung Ban, Hyun× Yoshimori, Atsushi× Aoki, Ichio× Jürgen, Bajorath× Nakamura, Hiroyuki× Akira, Sumiyoshi× Ichio, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid- (A) fibrillation process. Gd-DO3A-Comp.B inhibited Aß aggregation significantly and detected the fibril growth at 20 uM of AB with 10 uM of probe concentration by T1-weighted MR imaging. | |||||
| 書誌情報 |
RSC Advances 巻 12, p. 5027-5030, 発行日 2022-05 |
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| 出版者 | ||||||
| 出版者 | The Royal Society of Chemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2046-2069 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/D2RA00614F | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1039/D2RA00614F | |||||
