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Development of radio-Pt-based agents for targeted Auger electron therapy ~from radionuclide production to radio-labeling and biological evaluation
https://repo.qst.go.jp/records/85007
https://repo.qst.go.jp/records/850075b8cf5d9-8785-4a7e-9910-5efc0233abec
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-02-16 | |||||
| タイトル | ||||||
| タイトル | Development of radio-Pt-based agents for targeted Auger electron therapy ~from radionuclide production to radio-labeling and biological evaluation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Honoka, Obata
× Honoka, Obata× Honoka, Obata |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recently, targeted radionuclide therapy (TRT) with radionuclide-derived short-range radiation has been growing rapidly. Due to their nano-scale range (2–500 nm), Auger electrons (Auger e−) have the potential to induce physiochemical damage to biomolecules smaller than a single cell, meaning that it is necessary to transport Auger e−-emitting radiopharmaceuticals to cellular regions that are sensitive to Auger e−. DNA is a prime target of Auger e− TRT; however, proper drug design has remained elusive. The DNA-damaging effect of Auger e− is maximized by an efficient interaction with DNA when Auger e− emitters are as close as possible to DNA. In this regard, radio-Pt is suitable for Auger e− TRT targeting DNA efficiently because of the unique DNA-binding ability of Pt. We have established a novel production method of no-carrier–added radio-Pt (n.c.a. 191Pt emitting Auger electrons) and developed labeling methods for n.c.a. 191Pt. In this presentation, I will introduce the series of research on 191Pt from the development of 191Pt-labeled agents to their biological evaluation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | On the Horizon: Novel Isotopes and Future Leaders | |||||
| 発表年月日 | ||||||
| 日付 | 2022-02-24 | |||||
| 日付タイプ | Issued | |||||
