{"created":"2023-05-15T15:02:41.897333+00:00","id":85007,"links":{},"metadata":{"_buckets":{"deposit":"625e72f3-b450-40c1-aa6b-087512fcbcc9"},"_deposit":{"created_by":1,"id":"85007","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85007"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085007","sets":["10:29"]},"author_link":["1034556","1034555"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-02-24","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently, targeted radionuclide therapy (TRT) with radionuclide-derived short-range radiation has been growing rapidly. Due to their nano-scale range (2–500 nm), Auger electrons (Auger e−) have the potential to induce physiochemical damage to biomolecules smaller than a single cell, meaning that it is necessary to transport Auger e−-emitting radiopharmaceuticals to cellular regions that are sensitive to Auger e−. DNA is a prime target of Auger e− TRT; however, proper drug design has remained elusive. The DNA-damaging effect of Auger e− is maximized by an efficient interaction with DNA when Auger e− emitters are as close as possible to DNA. In this regard, radio-Pt is suitable for Auger e− TRT targeting DNA efficiently because of the unique DNA-binding ability of Pt. We have established a novel production method of no-carrier–added radio-Pt (n.c.a. 191Pt emitting Auger electrons) and developed labeling methods for n.c.a. 191Pt. In this presentation, I will introduce the series of research on 191Pt from the development of 191Pt-labeled agents to their biological evaluation.\n\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"On the Horizon: Novel Isotopes and Future Leaders","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Honoka, Obata"}],"nameIdentifiers":[{"nameIdentifier":"1034555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honoka, Obata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1034556","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Development of radio-Pt-based agents for targeted Auger electron therapy ~from radionuclide production to radio-labeling and biological evaluation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of radio-Pt-based agents for targeted Auger electron therapy ~from radionuclide production to radio-labeling and biological evaluation"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-16"},"publish_date":"2022-02-16","publish_status":"0","recid":"85007","relation_version_is_last":true,"title":["Development of radio-Pt-based agents for targeted Auger electron therapy ~from radionuclide production to radio-labeling and biological evaluation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:35:06.231970+00:00"}