WEKO3
アイテム
Preferential radiosensitization to glioblastoma cancer stem cell‑like cells by a Hsp90 inhibitor, N‑vinylpyrrolidone‑AUY922
https://repo.qst.go.jp/records/84905
https://repo.qst.go.jp/records/84905876bfc42-c8bb-49d3-950f-77c1ea571fb9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-02-04 | |||||
| タイトル | ||||||
| タイトル | Preferential radiosensitization to glioblastoma cancer stem cell‑like cells by a Hsp90 inhibitor, N‑vinylpyrrolidone‑AUY922 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Toshiaki, Tani
× Toshiaki, Tani× Naomi , Tojo× Ken, Ohnishi× Toshiaki, Tani |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study examined the radiosensitization induced by a heat shock protein 90 inhibitor, N‑vinylpyrrolidone (NVP)‑AUY922, in CD133‑positive cells in a hypoxic area of T98G spheroids. CD133‑positive cells that are induced in the hypoxic microenvironment of spheroids have previously been reported to exhibit cancer stem cell‑like properties. The present study used CD133‑positive cells from a glioblastoma cell line (T98G) as cancer stem cell‑like cells. CD133‑positive and negative cells were sorted from T98G spheroids using fluorescence‑activated cell sorting and used for colony formation assay. Colony formation assay results indicated that NVP‑AUY922 enhanced radiosensitivity more strongly in CD133‑positive cells compared with CD133‑negative cells. This result showed that NVP‑AUY922 was a preferential radiosensitization candidate targeting glioblastoma cancer stem cells. The mechanisms underlying radiosensitization by NVP‑AUY922 are discussed in relation to the properties of cancer stem cells. Overall, HIF‑1α inhibition by NVP‑AUY922 may induce higher sensitization of cancer stem cells to radiation. | |||||
| 書誌情報 |
Oncology Letters 巻 23, 号 3, p. 102, 発行日 2022-03 |
|||||
| 出版者 | ||||||
| 出版者 | Spandidos Publications | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1792-1074 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3892/ol.2022.13222 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.spandidos-publications.com/10.3892/ol.2022.13222 | |||||
