@article{oai:repo.qst.go.jp:00084905,
 author = {Toshiaki, Tani and Naomi , Tojo and Ken, Ohnishi and Toshiaki, Tani},
 issue = {3},
 journal = {Oncology Letters},
 month = {Mar},
 note = {The present study examined the radiosensitization induced by a heat shock protein 90 inhibitor, N‑vinylpyrrolidone (NVP)‑AUY922, in CD133‑positive cells in a hypoxic area of T98G spheroids. CD133‑positive cells that are induced in the hypoxic microenvironment of spheroids have previously been reported to exhibit cancer stem cell‑like properties. The present study used CD133‑positive cells from a glioblastoma cell line (T98G) as cancer stem cell‑like cells. CD133‑positive and negative cells were sorted from T98G spheroids using fluorescence‑activated cell sorting and used for colony formation assay. Colony formation assay results indicated that NVP‑AUY922 enhanced radiosensitivity more strongly in CD133‑positive cells compared with CD133‑negative cells. This result showed that NVP‑AUY922 was a preferential radiosensitization candidate targeting glioblastoma cancer stem cells. The mechanisms underlying radiosensitization by NVP‑AUY922 are discussed in relation to the properties of cancer stem cells. Overall, HIF‑1α inhibition by NVP‑AUY922 may induce higher sensitization of cancer stem cells to radiation.},
 title = {Preferential radiosensitization to glioblastoma cancer stem cell‑like cells by a Hsp90 inhibitor, N‑vinylpyrrolidone‑AUY922},
 volume = {23},
 year = {2022}
}