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Redox-modulation, suppression of “oncogenic” superoxide and induction of apoptosis in Burkitt's lymphoma cells using Geum urbanum L. extracts
https://repo.qst.go.jp/records/84674
https://repo.qst.go.jp/records/846745918a014-7d48-491d-b2da-b297d1766c03
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-01-11 | |||||
| タイトル | ||||||
| タイトル | Redox-modulation, suppression of “oncogenic” superoxide and induction of apoptosis in Burkitt's lymphoma cells using Geum urbanum L. extracts | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mileva, Milka
× Mileva, Milka× Dimitrova, Lyudmila× Popova, Milena× Bankova, Vassya× Krastev, Dimo× Najdenski, Hristo× Zhelev, Zhivko× Ichio, Aoki× Bakalova, Rumiana× Ichio, Aoki× Bakalova, Rumiana |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract: Burkitt’s lymphoma is a highly aggressive type of non-Hodgkin’s lymphoma, linked to the Epstein-Barr virus, which induces oxidative stress and DNA damage in the infected cells. We investigated the cytotoxicity and redox-modulating ability of ethyl acetate (EtOAc) and n-butanol (n-BuOH) extracts from Geum urbanum L. roots and aerial parts on Burkitt`s lymphoma cells (BLC), to elucidate their impact on oxidative stress and cell survival. BLC Raji was treated with EtOAc and n-BuOH extracts to analyze: cell viability; induction of apoptosis; hydroperoxides and reactive nitrogen species (RNS) by 2’,7’-dichlorodihydrofluorescein assay; superoxide by dihydroethidium assay; total antioxidant capacity by TAC assay. All extracts suppressed cell growth and induce apoptosis. n-BuOH extracts possessed higher cytotoxicity and pro-apoptotic activity compared to EtOAc. The fractions decreased the hydroperoxides and RNS levels. There was no correlation between the DCF fluorescence in the treated cells and their viability (R = –0.3722; p > 0.05). Root extracts decreased the superoxide level, while the leaf extracts did not. There was a good correlation between the dihydroethidium fluorescence in the treated cells and their viability (R = 0.9843; p < 0.01). All extracts increased the TAC of BLC. G. urbanum extracts serve as redox-modulators and anti-inflammatory compounds, decreasing the intracellular level of “oncogenic” superoxide and cell proliferation. |
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| 書誌情報 |
International Journal Bioautomation 巻 25, 号 4, p. 315-330, 発行日 2022-01 |
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| 出版者 | ||||||
| 出版者 | Institute of Biophysics and Biomedical Engineering at the Bulgarian Academy of Sciences | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1314-1902 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.7546/ijba.2021.25.4.000795 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://biomed.bas.bg/bioautomation/2021/vol_25.4/toc.html | |||||
