{"created":"2023-05-15T15:02:26.852305+00:00","id":84674,"links":{},"metadata":{"_buckets":{"deposit":"04746531-d152-4c25-a8c3-d68e11ae38d0"},"_deposit":{"created_by":1,"id":"84674","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84674"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084674","sets":["1"]},"author_link":["1021931","1021932","1021928","1021936","1021935","1021926","1021929","1021930","1021934","1021927","1021933"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"330","bibliographicPageStart":"315","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"International Journal Bioautomation"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract: Burkitt’s lymphoma is a highly aggressive type of non-Hodgkin’s lymphoma, linked to the Epstein-Barr virus, which induces oxidative stress and DNA damage in the infected cells. We investigated the cytotoxicity and redox-modulating ability of ethyl acetate (EtOAc) and n-butanol (n-BuOH) extracts from Geum urbanum L. roots and aerial parts on Burkitt`s lymphoma cells (BLC), to elucidate their impact on oxidative stress and cell survival. BLC Raji was treated with EtOAc and n-BuOH extracts to analyze: cell viability; induction of apoptosis; hydroperoxides and reactive nitrogen species (RNS) by 2’,7’-dichlorodihydrofluorescein assay; superoxide by dihydroethidium assay; total antioxidant capacity by TAC assay. All extracts suppressed cell growth and induce apoptosis. n-BuOH extracts possessed higher cytotoxicity and pro-apoptotic activity compared to EtOAc. The fractions decreased the hydroperoxides and RNS levels.\nThere was no correlation between the DCF fluorescence in the treated cells and their viability (R = –0.3722; p > 0.05). Root extracts decreased the superoxide level, while the leaf extracts did not. There was a good correlation between the dihydroethidium fluorescence in the treated cells and their viability (R = 0.9843; p < 0.01). All extracts increased the TAC of BLC. G. urbanum extracts serve as redox-modulators and anti-inflammatory compounds, decreasing the intracellular level of “oncogenic” superoxide and cell proliferation.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Institute of Biophysics and Biomedical Engineering at the Bulgarian Academy of Sciences"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.7546/ijba.2021.25.4.000795","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://biomed.bas.bg/bioautomation/2021/vol_25.4/toc.html","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1314-1902","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mileva, Milka"}],"nameIdentifiers":[{"nameIdentifier":"1021926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dimitrova, Lyudmila"}],"nameIdentifiers":[{"nameIdentifier":"1021927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Popova, Milena"}],"nameIdentifiers":[{"nameIdentifier":"1021928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bankova, Vassya"}],"nameIdentifiers":[{"nameIdentifier":"1021929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Krastev, Dimo"}],"nameIdentifiers":[{"nameIdentifier":"1021930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Najdenski, Hristo"}],"nameIdentifiers":[{"nameIdentifier":"1021931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhelev, Zhivko"}],"nameIdentifiers":[{"nameIdentifier":"1021932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki"}],"nameIdentifiers":[{"nameIdentifier":"1021933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"1021934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021936","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Redox-modulation, suppression of “oncogenic” superoxide and induction of apoptosis in Burkitt's lymphoma cells using Geum urbanum L. extracts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Redox-modulation, suppression of “oncogenic” superoxide and induction of apoptosis in Burkitt's lymphoma cells using Geum urbanum L. extracts"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-11"},"publish_date":"2022-01-11","publish_status":"0","recid":"84674","relation_version_is_last":true,"title":["Redox-modulation, suppression of “oncogenic” superoxide and induction of apoptosis in Burkitt's lymphoma cells using Geum urbanum L. extracts"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:16:23.409272+00:00"}