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Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network
https://repo.qst.go.jp/records/84551
https://repo.qst.go.jp/records/84551128cb7ff-b315-4640-b820-0ce6329a10f4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-25 | |||||
| タイトル | ||||||
| タイトル | Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Toshiyuki, Hirabayashi
× Toshiyuki, Hirabayashi× Yuji, Nagai× Yukiko, Hori× Ken-ichi, Inoue× Ichio, Aoki× Takada, Masahiko× Tetsuya, Suhara× Makoto, Higuchi× Takafumi, Minamimoto× Toshiyuki, Hirabayashi× Yuji, Nagai× Yukiko, Hori× Ichio, Aoki× Tetsuya, Suhara× Makoto, Higuchi× Takafumi, Minamimoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Concurrent genetic neuromodulation and functional magnetic resonance imaging (fMRI) in primates has provided a valuable opportunity to assess the modified brain-wide operation in the resting state. However, its application to link the network operation with behavior still remains challenging. Here, we combined chemogenetic silencing of the primary somatosensory cortex (SI) with tactile fMRI and related behaviors in macaques. Focal chemogenetic silencing of functionally identified SI hand region impaired grasping behavior. The same silencing also attenuated hand stimulation-evoked fMRI signal at both the local silencing site and the anatomically and/or functionally connected downstream grasping network, suggesting altered network operation underlying the induced behavioral impairment. Furthermore, the hand region silencing unexpectedly disinhibited foot representation with accompanying behavioral hypersensitization. These results demonstrate that focal chemogenetic silencing with sensory fMRI in macaques unveils bidirectional network changes to generate multifaceted behavioral impairments, thereby opening a pivotal window toward elucidating the causal network operation underpinning higher brain functions in primates | |||||
| 書誌情報 |
Neuron 巻 109, 号 20, p. 3312-3322.e1–e5, 発行日 2021-10 |
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| 出版者 | ||||||
| 出版者 | Cell Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0896-6273 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34672984 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.neuron.2021.08.032 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0896627321006498?via%3Dihub | |||||
