{"created":"2023-05-15T15:02:21.319168+00:00","id":84551,"links":{},"metadata":{"_buckets":{"deposit":"8a173a90-7389-47e2-b2a6-c93795c44e9e"},"_deposit":{"created_by":1,"id":"84551","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84551"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084551","sets":["1"]},"author_link":["1020444","1020437","1020443","1020441","1020450","1020451","1020446","1020439","1020438","1020445","1020442","1020449","1020447","1020440","1020436","1020448"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"20","bibliographicPageEnd":"3322.e1–e5","bibliographicPageStart":"3312","bibliographicVolumeNumber":"109","bibliographic_titles":[{"bibliographic_title":"Neuron"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Concurrent genetic neuromodulation and functional magnetic resonance imaging (fMRI) in primates has provided a valuable opportunity to assess the modified brain-wide operation in the resting state. However, its application to link the network operation with behavior still remains challenging. Here, we combined chemogenetic silencing of the primary somatosensory cortex (SI) with tactile fMRI and related behaviors in macaques. Focal chemogenetic silencing of functionally identified SI hand region impaired grasping behavior. The same silencing also attenuated hand stimulation-evoked fMRI signal at both the local silencing site and the anatomically and/or functionally connected downstream grasping network, suggesting altered network operation underlying the induced behavioral impairment. Furthermore, the hand region silencing unexpectedly disinhibited foot representation with accompanying behavioral hypersensitization. These results demonstrate that focal chemogenetic silencing with sensory fMRI in macaques unveils bidirectional network changes to generate multifaceted behavioral impairments, thereby opening a pivotal window toward elucidating the causal network operation underpinning higher brain functions in primates","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Cell Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34672984","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neuron.2021.08.032","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S0896627321006498?via%3Dihub","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0896-6273","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Toshiyuki, Hirabayashi"}],"nameIdentifiers":[{"nameIdentifier":"1020436","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuji, Nagai"}],"nameIdentifiers":[{"nameIdentifier":"1020437","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yukiko, Hori"}],"nameIdentifiers":[{"nameIdentifier":"1020438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ken-ichi, Inoue"}],"nameIdentifiers":[{"nameIdentifier":"1020439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki"}],"nameIdentifiers":[{"nameIdentifier":"1020440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takada, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"1020441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Suhara"}],"nameIdentifiers":[{"nameIdentifier":"1020442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi"}],"nameIdentifiers":[{"nameIdentifier":"1020443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takafumi, Minamimoto"}],"nameIdentifiers":[{"nameIdentifier":"1020444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshiyuki, Hirabayashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuji, Nagai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yukiko, Hori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Suhara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takafumi, Minamimoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1020451","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-25"},"publish_date":"2021-10-25","publish_status":"0","recid":"84551","relation_version_is_last":true,"title":["Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:21:08.083021+00:00"}