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  1. 原著論文

First‑in‑human in vivo imaging and quantifcation of monoacylglycerol lipase in the brain: a PET study with 18F‑T‑401

https://repo.qst.go.jp/records/84537
https://repo.qst.go.jp/records/84537
79936b97-725b-4383-a053-fea7a959091d
Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-01-13
タイトル
タイトル First‑in‑human in vivo imaging and quantifcation of monoacylglycerol lipase in the brain: a PET study with 18F‑T‑401
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Keisuke, Takahata

× Keisuke, Takahata

WEKO 1058391

Keisuke, Takahata

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Chie, Seki

× Chie, Seki

WEKO 1058392

Chie, Seki

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Yasuyuki, Kimura

× Yasuyuki, Kimura

WEKO 1058393

Yasuyuki, Kimura

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Manabu, Kubota

× Manabu, Kubota

WEKO 1058394

Manabu, Kubota

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Masanori, Ichise

× Masanori, Ichise

WEKO 1058395

Masanori, Ichise

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Yasunori, Sano

× Yasunori, Sano

WEKO 1058396

Yasunori, Sano

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Yamamoto, Yasuharu

× Yamamoto, Yasuharu

WEKO 1058397

Yamamoto, Yasuharu

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Kenji, Tagai

× Kenji, Tagai

WEKO 1058398

Kenji, Tagai

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Hitoshi, Shimada

× Hitoshi, Shimada

WEKO 1058399

Hitoshi, Shimada

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Soichiro, Kitamura

× Soichiro, Kitamura

WEKO 1058400

Soichiro, Kitamura

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Kiwamu, Matsuoka

× Kiwamu, Matsuoka

WEKO 1058401

Kiwamu, Matsuoka

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Hironobu, Endo

× Hironobu, Endo

WEKO 1058402

Hironobu, Endo

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Hitoshi, Shinoto

× Hitoshi, Shinoto

WEKO 1058403

Hitoshi, Shinoto

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Kazunori, Kawamura

× Kazunori, Kawamura

WEKO 1058404

Kazunori, Kawamura

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Zhang, Ming-Rong

× Zhang, Ming-Rong

WEKO 1058405

Zhang, Ming-Rong

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Yuhei, Takado

× Yuhei, Takado

WEKO 1058406

Yuhei, Takado

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Makoto, Higuchi

× Makoto, Higuchi

WEKO 1058407

Makoto, Higuchi

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Keisuke, Takahata

× Keisuke, Takahata

WEKO 1058408

en Keisuke, Takahata

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Chie, Seki

× Chie, Seki

WEKO 1058409

en Chie, Seki

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Yasuyuki, Kimura

× Yasuyuki, Kimura

WEKO 1058410

en Yasuyuki, Kimura

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Manabu, Kubota

× Manabu, Kubota

WEKO 1058411

en Manabu, Kubota

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Masanori, Ichise

× Masanori, Ichise

WEKO 1058412

en Masanori, Ichise

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Yasunori, Sano

× Yasunori, Sano

WEKO 1058413

en Yasunori, Sano

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Yamamoto, Yasuharu

× Yamamoto, Yasuharu

WEKO 1058414

en Yamamoto, Yasuharu

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Kenji, Tagai

× Kenji, Tagai

WEKO 1058415

en Kenji, Tagai

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Hitoshi, Shimada

× Hitoshi, Shimada

WEKO 1058416

en Hitoshi, Shimada

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Soichiro, Kitamura

× Soichiro, Kitamura

WEKO 1058417

en Soichiro, Kitamura

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Kiwamu, Matsuoka

× Kiwamu, Matsuoka

WEKO 1058418

en Kiwamu, Matsuoka

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Hironobu, Endo

× Hironobu, Endo

WEKO 1058419

en Hironobu, Endo

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Hitoshi, Shinoto

× Hitoshi, Shinoto

WEKO 1058420

en Hitoshi, Shinoto

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Kazunori, Kawamura

× Kazunori, Kawamura

WEKO 1058421

en Kazunori, Kawamura

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Zhang, Ming-Rong

× Zhang, Ming-Rong

WEKO 1058422

en Zhang, Ming-Rong

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Yuhei, Takado

× Yuhei, Takado

WEKO 1058423

en Yuhei, Takado

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Makoto, Higuchi

× Makoto, Higuchi

WEKO 1058424

en Makoto, Higuchi

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抄録
内容記述タイプ Abstract
内容記述 Purpose Monoacylglycerol lipase (MAGL) regulates cannabinoid neurotransmission and the pro-infammatory arachidonic
acid pathway by degrading endocannabinoids. MAGL inhibitors may accordingly act as cannabinoid-potentiating and antiinfammatory agents. Although MAGL dysfunction has been implicated in neuropsychiatric disorders, it has never been
visualized in vivo in human brain. The primary objective of the current study was to visualize MAGL in the human brain
using the novel PET ligand 18F-T-401.
Methods Seven healthy males underwent 120-min dynamic 18F-T-401-PET scans with arterial blood sampling. Six subjects also underwent a second PET scan with 18F-T-401 within 2 weeks of the frst scan. For quantifcation of MAGL in the
human brain, kinetic analyses using one- and two-tissue compartment models (1TCM and 2TCM, respectively), along with
multilinear analysis (MA1) and Logan graphical analysis, were performed. Time-stability and test–retest reproducibility of
18F-T-401-PET were also evaluated.
Results 18F-T-401 showed rapid uptake and gradual washout from the brain. Logan graphical analysis showed linearity in
all subjects, indicating reversible radioligand kinetics. Using a metabolite-corrected arterial input function, MA1 estimated
regional total distribution volume (VT) values by best identifability. VT values were highest in the cerebral cortex, moderate
in the thalamus and putamen, and lowest in white matter and the brainstem, which was in agreement with regional MAGL
expression in the human brain. Time-stability analysis showed that MA1 estimated VT values with a minimal bias even using
truncated 60-min scan data. Test–retest reliability was also excellent with the use of MA1.
Conclusions Here, we provide the frst demonstration of in vivo visualization of MAGL in the human brain. 18F-T-401 showed
excellent test–retest reliability, reversible kinetics, and stable estimation of VT values consistent with known regional MAGL
expressions. PET with 18F-T-401-PET is promising tool for measurement of central MAGL.
書誌情報 European Journal of Nuclear Medicine and Molecular Imaging

巻 49, p. 3150-3161, 発行日 2022-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1619-7070
PubMed番号
識別子タイプ PMID
関連識別子 35022846
DOI
識別子タイプ DOI
関連識別子 10.1007/s00259-021-05671-y
関連サイト
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00259-021-05671-y
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