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First‑in‑human in vivo imaging and quantifcation of monoacylglycerol lipase in the brain: a PET study with 18F‑T‑401
https://repo.qst.go.jp/records/84537
https://repo.qst.go.jp/records/8453779936b97-725b-4383-a053-fea7a959091d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-01-13 | |||||
| タイトル | ||||||
| タイトル | First‑in‑human in vivo imaging and quantifcation of monoacylglycerol lipase in the brain: a PET study with 18F‑T‑401 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Keisuke, Takahata
× Keisuke, Takahata× Chie, Seki× Yasuyuki, Kimura× Manabu, Kubota× Masanori, Ichise× Yasunori, Sano× Yamamoto, Yasuharu× Kenji, Tagai× Hitoshi, Shimada× Soichiro, Kitamura× Kiwamu, Matsuoka× Hironobu, Endo× Hitoshi, Shinoto× Kazunori, Kawamura× Zhang, Ming-Rong× Yuhei, Takado× Makoto, Higuchi× Keisuke, Takahata× Chie, Seki× Yasuyuki, Kimura× Manabu, Kubota× Masanori, Ichise× Yasunori, Sano× Yamamoto, Yasuharu× Kenji, Tagai× Hitoshi, Shimada× Soichiro, Kitamura× Kiwamu, Matsuoka× Hironobu, Endo× Hitoshi, Shinoto× Kazunori, Kawamura× Zhang, Ming-Rong× Yuhei, Takado× Makoto, Higuchi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose Monoacylglycerol lipase (MAGL) regulates cannabinoid neurotransmission and the pro-infammatory arachidonic acid pathway by degrading endocannabinoids. MAGL inhibitors may accordingly act as cannabinoid-potentiating and antiinfammatory agents. Although MAGL dysfunction has been implicated in neuropsychiatric disorders, it has never been visualized in vivo in human brain. The primary objective of the current study was to visualize MAGL in the human brain using the novel PET ligand 18F-T-401. Methods Seven healthy males underwent 120-min dynamic 18F-T-401-PET scans with arterial blood sampling. Six subjects also underwent a second PET scan with 18F-T-401 within 2 weeks of the frst scan. For quantifcation of MAGL in the human brain, kinetic analyses using one- and two-tissue compartment models (1TCM and 2TCM, respectively), along with multilinear analysis (MA1) and Logan graphical analysis, were performed. Time-stability and test–retest reproducibility of 18F-T-401-PET were also evaluated. Results 18F-T-401 showed rapid uptake and gradual washout from the brain. Logan graphical analysis showed linearity in all subjects, indicating reversible radioligand kinetics. Using a metabolite-corrected arterial input function, MA1 estimated regional total distribution volume (VT) values by best identifability. VT values were highest in the cerebral cortex, moderate in the thalamus and putamen, and lowest in white matter and the brainstem, which was in agreement with regional MAGL expression in the human brain. Time-stability analysis showed that MA1 estimated VT values with a minimal bias even using truncated 60-min scan data. Test–retest reliability was also excellent with the use of MA1. Conclusions Here, we provide the frst demonstration of in vivo visualization of MAGL in the human brain. 18F-T-401 showed excellent test–retest reliability, reversible kinetics, and stable estimation of VT values consistent with known regional MAGL expressions. PET with 18F-T-401-PET is promising tool for measurement of central MAGL. |
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| 書誌情報 |
European Journal of Nuclear Medicine and Molecular Imaging 巻 49, p. 3150-3161, 発行日 2022-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1619-7070 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35022846 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00259-021-05671-y | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s00259-021-05671-y | |||||
