{"created":"2023-05-15T15:02:20.671826+00:00","id":84537,"links":{},"metadata":{"_buckets":{"deposit":"ca94bee8-8f2b-412f-87d9-3e350da7e1bc"},"_deposit":{"created_by":1,"id":"84537","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84537"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084537","sets":["1"]},"author_link":["1058396","1058399","1058418","1058416","1058407","1058415","1058408","1058409","1058393","1058398","1058420","1058392","1058411","1058401","1058423","1058404","1058410","1058394","1058419","1058422","1058413","1058417","1058406","1058424","1058400","1058414","1058391","1058405","1058421","1058403","1058402","1058395","1058397","1058412"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"3161","bibliographicPageStart":"3150","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"European Journal of Nuclear Medicine and Molecular Imaging"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose Monoacylglycerol lipase (MAGL) regulates cannabinoid neurotransmission and the pro-infammatory arachidonic \nacid pathway by degrading endocannabinoids. MAGL inhibitors may accordingly act as cannabinoid-potentiating and antiinfammatory agents. Although MAGL dysfunction has been implicated in neuropsychiatric disorders, it has never been \nvisualized in vivo in human brain. The primary objective of the current study was to visualize MAGL in the human brain \nusing the novel PET ligand 18F-T-401.\nMethods Seven healthy males underwent 120-min dynamic 18F-T-401-PET scans with arterial blood sampling. Six subjects also underwent a second PET scan with 18F-T-401 within 2 weeks of the frst scan. For quantifcation of MAGL in the \nhuman brain, kinetic analyses using one- and two-tissue compartment models (1TCM and 2TCM, respectively), along with \nmultilinear analysis (MA1) and Logan graphical analysis, were performed. Time-stability and test–retest reproducibility of \n18F-T-401-PET were also evaluated.\nResults 18F-T-401 showed rapid uptake and gradual washout from the brain. Logan graphical analysis showed linearity in \nall subjects, indicating reversible radioligand kinetics. Using a metabolite-corrected arterial input function, MA1 estimated \nregional total distribution volume (VT) values by best identifability. VT values were highest in the cerebral cortex, moderate \nin the thalamus and putamen, and lowest in white matter and the brainstem, which was in agreement with regional MAGL \nexpression in the human brain. Time-stability analysis showed that MA1 estimated VT values with a minimal bias even using \ntruncated 60-min scan data. Test–retest reliability was also excellent with the use of MA1.\nConclusions Here, we provide the frst demonstration of in vivo visualization of MAGL in the human brain. 18F-T-401 showed \nexcellent test–retest reliability, reversible kinetics, and stable estimation of VT values consistent with known regional MAGL \nexpressions. PET with 18F-T-401-PET is promising tool for measurement of central MAGL.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"35022846","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00259-021-05671-y","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00259-021-05671-y","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1619-7070","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Keisuke, Takahata"}],"nameIdentifiers":[{"nameIdentifier":"1058391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chie, Seki"}],"nameIdentifiers":[{"nameIdentifier":"1058392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuyuki, Kimura"}],"nameIdentifiers":[{"nameIdentifier":"1058393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Manabu, Kubota"}],"nameIdentifiers":[{"nameIdentifier":"1058394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanori, Ichise"}],"nameIdentifiers":[{"nameIdentifier":"1058395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasunori, Sano"}],"nameIdentifiers":[{"nameIdentifier":"1058396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Yasuharu"}],"nameIdentifiers":[{"nameIdentifier":"1058397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenji, Tagai"}],"nameIdentifiers":[{"nameIdentifier":"1058398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitoshi, Shimada"}],"nameIdentifiers":[{"nameIdentifier":"1058399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Soichiro, Kitamura"}],"nameIdentifiers":[{"nameIdentifier":"1058400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiwamu, Matsuoka"}],"nameIdentifiers":[{"nameIdentifier":"1058401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hironobu, Endo"}],"nameIdentifiers":[{"nameIdentifier":"1058402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitoshi, Shinoto"}],"nameIdentifiers":[{"nameIdentifier":"1058403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Kawamura"}],"nameIdentifiers":[{"nameIdentifier":"1058404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1058405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuhei, Takado"}],"nameIdentifiers":[{"nameIdentifier":"1058406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi"}],"nameIdentifiers":[{"nameIdentifier":"1058407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Keisuke, Takahata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chie, Seki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuyuki, Kimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Manabu, Kubota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanori, Ichise","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasunori, Sano","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Yasuharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenji, Tagai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitoshi, Shimada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Soichiro, Kitamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiwamu, Matsuoka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hironobu, Endo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitoshi, Shinoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Kawamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuhei, Takado","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058424","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"First‑in‑human in vivo imaging and quantifcation  of monoacylglycerol lipase in the brain: a PET study with 18F‑T‑401","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"First‑in‑human in vivo imaging and quantifcation  of monoacylglycerol lipase in the brain: a PET study with 18F‑T‑401"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-13"},"publish_date":"2022-01-13","publish_status":"0","recid":"84537","relation_version_is_last":true,"title":["First‑in‑human in vivo imaging and quantifcation  of monoacylglycerol lipase in the brain: a PET study with 18F‑T‑401"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T16:51:11.914616+00:00"}