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アイテム
Exploring the effect of aquaporin-4 suppression on cell membrane water exchange in a mouse model of brain ischemia using diffusion-weighted MRI
https://repo.qst.go.jp/records/84263
https://repo.qst.go.jp/records/842630089a3d0-6bb9-42e6-9096-1116433e8992
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-12-17 | |||||
| タイトル | ||||||
| タイトル | Exploring the effect of aquaporin-4 suppression on cell membrane water exchange in a mouse model of brain ischemia using diffusion-weighted MRI | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takuya, Urushihata
× Takuya, Urushihata× Hiroyuki, Takuwa× Takahashi, Manami× Yasuhiko, Tachibana× Kershaw, Jeffrey× Nobuhiro, Nitta× Sayaka, Shibata× Yasui, Masato× Makoto, Higuchi× Takayuki, Obata× Takuya, Urushihata× Hiroyuki, Takuwa× Takahashi, Manami× Yasuhiko, Tachibana× Kershaw, Jeffrey× Nobuhiro, Nitta× Sayaka, Shibata× Makoto, Higuchi× Takayuki, Obata |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We measured multi-b-value multi-diffusion-time (MbMTd) DWI and compared ADCs in the ischemic focii of aquaporin4-knockout (AQP4-KO) and wild type (WT) mice. In the ischemic region, AQP4-KO mice showed lower ADCs compared to WT mice, whereas higher ADCs were observed in the contralateral region. In addition, we compared estimates of cell membrane water exchange time obtained by fitting a two-compartment exchange model to the DWI signal. The exchange-time was approximately 2.5 times longer for the AQP4-KO mice than for the WT mice. These results suggest that MbMTd DWI may be useful for in vivo research and clinical diagnosis of AQP4-related diseases. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ISMRM 2021 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-05-20 | |||||
| 日付タイプ | Issued | |||||
