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Evaluation of sodium orthovanadate as a radioprotective agent under total-body irradiation and partial-body irradiation conditions in mice
https://repo.qst.go.jp/records/84252
https://repo.qst.go.jp/records/842523570fb97-16df-44ea-bf48-c894c559f1b0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-07 | |||||
| タイトル | ||||||
| タイトル | Evaluation of sodium orthovanadate as a radioprotective agent under total-body irradiation and partial-body irradiation conditions in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishiyama, Yuichi
× Nishiyama, Yuichi× Akinori, Morita× Wang, Bing× Sakai, Takuma× Ramadhani, Dwi× Hidetoshi Satoh× Tanaka, Kaoru× Sasatani, Megumi× Ochi, Shintaro× Tominaga, Masahide× Hitoshi Ikushima× Ueno, Junji× Nenoi, Mitsuru× Aoki, Shinya× Yuichi, Nishiyama× Akinori, Morita× Bing, Wang× Takuma, Sakai× Ramadhani, Dwi× Kaoru, Tanaka× Megumi, Sasatani× Shintaro, Ochi× Mitsuru, Nenoi× Shinya, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Our previous study indicated that sodium orthovanadate (vanadate), a strong inhibitor of p53, effectively suppressed the lethality from the hematopoietic (HP) and gastrointestinal (GI) syndromes after 12 Gy total-body irradiation (TBI) in mice. This conclusion, however, was inconsistent with the fact that p53 plays a radioprotective role in the intestinal epithelium. The death after TBI of around 12 Gy was attributed to a combined effect of HP and GI syndromes. To verify the effect from prophylactic administration of p53 inhibitor on protection of HP and GI syndromes, in this study, the radioprotective effects from vanadate were investigated in TBI and lower half-body irradiation (partial-body irradiation: PBI) mouse models. | |||||
| 書誌情報 |
International Journal of Radiation Biology 巻 97, 号 9, p. 1241-1251, 発行日 2021-06 |
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| 出版者 | ||||||
| 出版者 | Tayler & Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34125648 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/09553002.2021.1941377 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1080/09553002.2021.1941377 | |||||
