@article{oai:repo.qst.go.jp:00084252, author = {Nishiyama, Yuichi and Akinori, Morita and Wang, Bing and Sakai, Takuma and Ramadhani, Dwi and Hidetoshi Satoh and Tanaka, Kaoru and Sasatani, Megumi and Ochi, Shintaro and Tominaga, Masahide and Hitoshi Ikushima and Ueno, Junji and Nenoi, Mitsuru and Aoki, Shinya and Yuichi, Nishiyama and Akinori, Morita and Bing, Wang and Takuma, Sakai and Ramadhani, Dwi and Kaoru, Tanaka and Megumi, Sasatani and Shintaro, Ochi and Mitsuru, Nenoi and Shinya, Aoki}, issue = {9}, journal = {International Journal of Radiation Biology}, month = {Jun}, note = {Our previous study indicated that sodium orthovanadate (vanadate), a strong inhibitor of p53, effectively suppressed the lethality from the hematopoietic (HP) and gastrointestinal (GI) syndromes after 12 Gy total-body irradiation (TBI) in mice. This conclusion, however, was inconsistent with the fact that p53 plays a radioprotective role in the intestinal epithelium. The death after TBI of around 12 Gy was attributed to a combined effect of HP and GI syndromes. To verify the effect from prophylactic administration of p53 inhibitor on protection of HP and GI syndromes, in this study, the radioprotective effects from vanadate were investigated in TBI and lower half-body irradiation (partial-body irradiation: PBI) mouse models.}, pages = {1241--1251}, title = {Evaluation of sodium orthovanadate as a radioprotective agent under total-body irradiation and partial-body irradiation conditions in mice}, volume = {97}, year = {2021} }