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Hypoxia and Gap Junction Communication-Induced Bystander Effect
https://repo.qst.go.jp/records/84226
https://repo.qst.go.jp/records/84226211b2a8c-bca2-4fe1-9bc6-74c64b0d283f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-11-26 | |||||
| タイトル | ||||||
| タイトル | Hypoxia and Gap Junction Communication-Induced Bystander Effect | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Autsavapromporn, Narongchai
× Autsavapromporn, Narongchai× Kobayshi, Alisa× Ohsawa, Daisuke× Liu, Cuihua× Jaikang, Churdsak× Ahbrizal Tengku Ahamad, Tengku× Oikawa, Masakazu× Konishi, Teruaki× Alisa, Kobayashi× Daisuke, Ohsawa× Liu, Cuihua× Masakazu, Oikawa× Teruaki, Konishi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation-induced bystander effect (RIBE) has been identified as an important contributing factor to normal tissue damage and tumor development. However, the RIBE in cancer and normal cells under hypoxia remain unclear. In this study, we investigated the effect of gap junction intercellular communication (GJIC) in confluent A549 lung cancer and WI-38 normal lung cells after exposed to protons microbeam under hypoxic conditions. Following 6 hour incubation, cells were harvested and assayed for colony formation, micronucleus formation, chromosome aberration and western blotting. Our results show that there were differences of RIBE in bystander A549 and WI-38 cells under hypoxia and normoxia. The differences were also observed in the expression of HIF-1 in bystander A549 and WI-38 cells under both conditions. Interestingly, inhibition of GJIC showed a decreased in toxicity of hypoxic bystander A549 cells, but increased in hypoxic bystander WI-38 cells. We demonstrate the first time that GJIC protects bystander normal cells from toxicity while enhancing in bystander cancer cells under hypoxia. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本マイクロビーム生物研究会2021年度シンポジウム | |||||
| 発表年月日 | ||||||
| 日付 | 2021-12-14 | |||||
| 日付タイプ | Issued | |||||
