@misc{oai:repo.qst.go.jp:00084226,
 author = {Autsavapromporn, Narongchai and Kobayshi, Alisa and Ohsawa, Daisuke and Liu, Cuihua and Jaikang, Churdsak and Ahbrizal Tengku Ahamad, Tengku and Oikawa, Masakazu and Konishi, Teruaki and Alisa, Kobayashi and Daisuke, Ohsawa and Liu, Cuihua and Masakazu, Oikawa and Teruaki, Konishi},
 month = {Dec},
 note = {Radiation-induced bystander effect (RIBE) has been identified as an important contributing factor to normal tissue damage and tumor development. However, the RIBE in cancer and normal cells under hypoxia remain unclear. In this study, we investigated the effect of gap junction intercellular communication (GJIC) in confluent A549 lung cancer and WI-38 normal lung cells after exposed to protons microbeam under hypoxic conditions. Following 6 hour incubation, cells were harvested and assayed for colony formation, micronucleus formation, chromosome aberration and western blotting. Our results show that there were differences of RIBE in bystander A549 and WI-38 cells under hypoxia and normoxia. The differences were also observed in the expression of HIF-1 in bystander A549 and WI-38 cells under both conditions. Interestingly, inhibition of GJIC showed a decreased in toxicity of hypoxic bystander A549 cells, but increased in hypoxic bystander WI-38 cells. We demonstrate the first time that GJIC protects bystander normal cells from toxicity while enhancing in bystander cancer cells under hypoxia., 日本マイクロビーム生物研究会2021年度シンポジウム},
 title = {Hypoxia and Gap Junction Communication-Induced Bystander Effect},
 year = {2021}
}