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Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP457.
https://repo.qst.go.jp/records/84089
https://repo.qst.go.jp/records/840890188bead-267d-4175-914f-a6090d63b2ce
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-18 | |||||
| タイトル | ||||||
| タイトル | Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP457. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kimura, Yasuyuki
× Kimura, Yasuyuki× Takahata, Keisuke× Shimazaki, Toshiharu× Kitamura, Soichiro× Seki, Chie× Ikoma, Yoko× Ichise, Masanori× Kawamura, Kazunori× Yamada, Makiko× Ming-Rong, Zhang× Higuchi, Makoto× Nishino, Izumi× Suhara, Tetsuya× Yasuyuki, Kimura× Keisuke, Takahata× Soichiro, Kitamura× Chie, Seki× Yoko, Ikoma× Masanori, Ichise× Kazunori, Kawamura× Makiko, Yamada× Zhang, Ming-Rong× Makoto, Higuchi× Tetsuya, Suhara |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Histamine H receptor antagonists and inverse agonists have been extensively developed to treat sleep-wake, neurocognitive, and allied disorders. However, potential adverse effects, including insomnia, hampered the clinical use of these drugs, possibly due to their persistent interaction with the target molecules. The purpose of the present study was to estimate the pharmacokinetics and pharmacodynamics of enerisant, a novel antagonist and inverse agonist for histamine H receptors. | |||||
| 書誌情報 |
European journal of nuclear medicine and molecular imaging 巻 49, p. 1127-1135, 発行日 2021-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1619-7070 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34651222 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00259-021-05571-1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://link.springer.com/article/10.1007/s00259-021-05571-1 | |||||
