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Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets
https://repo.qst.go.jp/records/84086
https://repo.qst.go.jp/records/84086a5c18759-c478-4755-b28b-3e68eec179a8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-16 | |||||
| タイトル | ||||||
| タイトル | Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koki, Mimura
× Koki, Mimura× Yuji, Nagai× Ken-ichi, Inoue× Matsumoto, Jumpei× Yukiko, Hori× Chika, Sato× Kimura, Kei× Takashi, Okauchi× Toshiyuki, Hirabayashi× Nishijo, Hisao× Noriaki, Yahata× Takada, Masahiko× Tetsuya, Suhara× Makoto, Higuchi× Takafumi, Minamimoto× Koki, Mimura× Yuji, Nagai× Yukiko, Hori× Chika, Sato× Takashi, Okauchi× Toshiyuki, Hirabayashi× Noriaki, Yahata× Tetsuya, Suhara× Makoto, Higuchi× Takafumi, Minamimoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To interrogate particular neuronal pathways in nonhuman primates under natural and stress-free conditions, we applied designer receptors exclusively activated by designer drugs (DREADDs) technology to common marmosets. We injected adeno-associated virus vectors expressing the excitatory DREADD hM3Dq into the unilateral substantia nigra (SN) in fourmarmosets. Usingmulti-tracer positron emission tomography imaging, we detected DREADD expression in vivo, which was confirmed in nigrostriatal dopamine neurons by immunohistochemistry, as well as by assessed activation of the SN following agonist administration. The marmosets rotated in a contralateral direction relative to the activated side 30–90 min after consuming food containing the highly potent DREADD agonist deschloroclozapine (DCZ) but not on the following days without DCZ. These results indicate that non-invasive and reversible DREADD manipulation will extend the utility of marmosets as a primate model for linking neuronal activity and natural behavior in various contexts. |
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| 書誌情報 |
iScience 巻 24, 号 9, p. 103066, 発行日 2021-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2589-0042 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34568790 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.isci.2021.103066 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S2589004221010348 | |||||
