@article{oai:repo.qst.go.jp:00084086,
 author = {Koki, Mimura and Yuji, Nagai and Ken-ichi, Inoue and Matsumoto, Jumpei and Yukiko, Hori and Chika, Sato and Kimura, Kei and Takashi, Okauchi and Toshiyuki, Hirabayashi and Nishijo, Hisao and Noriaki, Yahata and Takada, Masahiko and Tetsuya, Suhara and Makoto, Higuchi and Takafumi, Minamimoto and Koki, Mimura and Yuji, Nagai and Yukiko, Hori and Chika, Sato and Takashi, Okauchi and Toshiyuki, Hirabayashi and Noriaki, Yahata and Tetsuya, Suhara and Makoto, Higuchi and Takafumi, Minamimoto},
 issue = {9},
 journal = {iScience},
 month = {Sep},
 note = {To interrogate particular neuronal pathways in nonhuman primates under natural
and stress-free conditions, we applied designer receptors exclusively activated
by designer drugs (DREADDs) technology to common marmosets. We injected
adeno-associated virus vectors expressing the excitatory DREADD hM3Dq into
the unilateral substantia nigra (SN) in fourmarmosets. Usingmulti-tracer positron
emission tomography imaging, we detected DREADD expression in vivo, which
was confirmed in nigrostriatal dopamine neurons by immunohistochemistry, as
well as by assessed activation of the SN following agonist administration. The
marmosets rotated in a contralateral direction relative to the activated side
30–90 min after consuming food containing the highly potent DREADD agonist
deschloroclozapine (DCZ) but not on the following days without DCZ. These results
indicate that non-invasive and reversible DREADD manipulation will extend
the utility of marmosets as a primate model for linking neuronal activity and natural
behavior in various contexts.},
 title = {Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets},
 volume = {24},
 year = {2021}
}