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Sequence dependence of nucleosomal DNA unwrapping
https://repo.qst.go.jp/records/83972
https://repo.qst.go.jp/records/83972ab83ae72-2cb7-4a6f-97a3-96af178edb56
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-11-02 | |||||
| タイトル | ||||||
| タイトル | Sequence dependence of nucleosomal DNA unwrapping | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tomoko, Sunami
× Tomoko, Sunami× Hidetoshi, Kono× Tomoko, Sunami× Hidetoshi, Kono |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The first nucleosomes positioned around the transcription start site, +1 nucleosomes, play critical roles in transcriptional regulation. We previously exhibited that AA/TT is enriched in the entry sites of +1 nucleosomes in yeast, and AA/TT regions in nucleosomes are more susceptible to MNase. To further understand the molecular mechanisms, we performed FRET analysis of nucleosomes reconstituted with and without A-tract at the entry/exit sites. Regardless of the sequences, nucleosomes show similar amount of the wrapped state in low salt concentrations. However, we found salt-induced DNA unwrapping occurs more easily in the A-tract nucleosomes, indicating the transition energy from the wrapped to unwrapped state might be lower for the A-tract nucleosomes. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第59回 日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-11-25 | |||||
| 日付タイプ | Issued | |||||
