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Microbeam irradiation and analysis on cytoplasm damage induced defensive cellular response.
https://repo.qst.go.jp/records/83923
https://repo.qst.go.jp/records/83923e4df1855-76e7-41b3-89d8-eb1b4471d147
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-08-06 | |||||
| タイトル | ||||||
| タイトル | Microbeam irradiation and analysis on cytoplasm damage induced defensive cellular response. | |||||
| タイトル | ||||||
| タイトル | マイクロビーム誘発細胞質損傷を起因とした防御的な細胞応答の解析 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Konishi, Teruaki
× Konishi, Teruaki× Kobayshi, Alisa× Ohsawa, Daisuke× Oikawa, Masakazu× Wang, Jun× Teruaki, Konishi× Alisa, Kobayashi× Daisuke, Ohsawa× Masakazu, Oikawa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Primary target of radiation is the cellular DNA, but consequence of cytoplasmic damage is yet to be understood. Taking advantage of SPICE-QST microbeam, we performed a cytoplasm targeted irradiation (Cyto-IR) of the WI-38 cells to investigate the cytoplasmic damage response. We focused on the activation of nuclear factor (erythroid-derived 2)-like 2 (NRF2) and its antioxidative signaling pathway. As a result, Cyto-IR induced mitochondria fragmentation, which accelerated the mitochondrial superoxide (MitoSOX) production. MitoSOX triggered the NRF2 nucleus translocation and upregulated the expression of its target genes, such as heme oxygenase 1. Overall, NRF2 antioxidative response is suggested to play a key role against DNA damage under cytoplasmic irradiation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第59回日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-11-25 | |||||
| 日付タイプ | Issued | |||||
