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Imaging urokinase plasminogen activator with a cyclic peptide-based PET tracer
https://repo.qst.go.jp/records/83859
https://repo.qst.go.jp/records/83859c24105b1-5bca-4630-81c2-2bb46d2e2c0c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-11-01 | |||||
| タイトル | ||||||
| タイトル | Imaging urokinase plasminogen activator with a cyclic peptide-based PET tracer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× Lin, Xie× Zhang, Yiding× Masayuki, Hanyu× Zhang, Ming-Rong× Kuan, Hu× Lin, Xie× Zhang, Yiding× Masayuki, Hanyu× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives Our goal is to develop a first-in-class cyclic peptide-based positron emission tomography (PET) tracer for imaging of uPA in cancers. Methods Three cyclic peptides (denoted as CAP-1 to 3) were labeled with Cu-64. PET imaging, ex vivo biodistribution, and histological examination were performed in mouse models bearing different types of tumors (glioma, breast, and colon) to evaluate the capacity and specificity of [64Cu]CAP-1/2/3 to target uPA in vivo. Results PET imaging with the three tracers in MC38 tumor-bearing mice perfectly delineated the expression level of uPA in the tumor tissues. Ex vivo biodistribution indicated that the tracers are majorly degraded in the liver and excreted out of the body through the kidney-bladder pathway. Conclusion We identified that cyclic peptide [64Cu]CPA-2 is a highly potential radiotracer for PET imaging of uPA in different kinds of tumors. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第61回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-11-04 | |||||
| 日付タイプ | Issued | |||||
