{"created":"2023-05-15T15:01:49.480120+00:00","id":83859,"links":{},"metadata":{"_buckets":{"deposit":"650b99b8-16f6-4cfa-8385-d07c862a5443"},"_deposit":{"created_by":1,"id":"83859","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83859"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083859","sets":["10:29"]},"author_link":["1011708","1011711","1011717","1011715","1011712","1011709","1011710","1011713","1011714","1011716"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-11-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives\nOur goal is to develop a first-in-class cyclic peptide-based positron emission tomography (PET) tracer for imaging of uPA in cancers.\n\nMethods\nThree cyclic peptides (denoted as CAP-1 to 3) were labeled with Cu-64. PET imaging, ex vivo biodistribution, and histological examination were performed in mouse models bearing different types of tumors (glioma, breast, and colon) to evaluate the capacity and specificity of [64Cu]CAP-1/2/3 to target uPA in vivo.\n\nResults\nPET imaging with the three tracers in MC38 tumor-bearing mice perfectly delineated the expression level of uPA in the tumor tissues. Ex vivo biodistribution indicated that the tracers are majorly degraded in the liver and excreted out of the body through the kidney-bladder pathway.\n\nConclusion\nWe identified that cyclic peptide [64Cu]CPA-2 is a highly potential radiotracer for PET imaging of uPA in different kinds of tumors.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第61回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuan, Hu"}],"nameIdentifiers":[{"nameIdentifier":"1011708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie"}],"nameIdentifiers":[{"nameIdentifier":"1011709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding"}],"nameIdentifiers":[{"nameIdentifier":"1011710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu"}],"nameIdentifiers":[{"nameIdentifier":"1011711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1011712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011717","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":" Imaging urokinase plasminogen activator with a cyclic peptide-based PET tracer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":" Imaging urokinase plasminogen activator with a cyclic peptide-based PET tracer"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-01"},"publish_date":"2021-11-01","publish_status":"0","recid":"83859","relation_version_is_last":true,"title":[" Imaging urokinase plasminogen activator with a cyclic peptide-based PET tracer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:58:51.647224+00:00"}