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DNAの水和構造から放射線損傷サイトを検証する
https://repo.qst.go.jp/records/83726
https://repo.qst.go.jp/records/837269abb2683-e645-4e89-87ba-a3498a6c97c8
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-07-30 | |||||
| タイトル | ||||||
| タイトル | DNAの水和構造から放射線損傷サイトを検証する | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
米谷, 佳晃
× 米谷, 佳晃× Yoshiteru, Yonetani |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Water has a non-negligible contribution to the radiation damage of DNA; however, many parts of the microscopic relationship still remain unclear. This article reviews our recent study in which we explore the microscopic behaviors of water and OH radicals interacting with DNA. Their accessibilities to the DNA backbone hydrogen sites (H1’–H5’) were calculated by using molecular dynamics (MD) simulation. The result found that the accessibility is well correlated with the site-dependent reactivity with OH radicals experimentally reported. This indicates that the DNA damage production is mainly determined by the atomistic features of accessibility. Compared with the previous study, the present MD provided a slightly improved correlation, which suggests importance of electrostatic interactions and DNA conformational fluctuation. | |||||
| 書誌情報 |
日本放射線化学会 会誌「放射線化学」 巻 112, p. 21-25, 発行日 2021-10 |
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| 出版者 | ||||||
| 出版者 | 日本放射線化学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2188-0115 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://radiation-chemistry.org/journal/ | |||||
