{"created":"2023-05-15T15:01:43.516122+00:00","id":83726,"links":{},"metadata":{"_buckets":{"deposit":"983466ab-f9ac-4e58-bebd-a7a1b0b628c1"},"_deposit":{"created_by":1,"id":"83726","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83726"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083726","sets":["11"]},"author_link":["1009265","1009264"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"25","bibliographicPageStart":"21","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"日本放射線化学会 会誌「放射線化学」"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Water has a non-negligible contribution to the radiation damage of DNA; however, many parts of the microscopic relationship still remain unclear. This article reviews our recent study in which we explore the microscopic behaviors of water and OH radicals interacting with DNA. Their accessibilities to the DNA backbone hydrogen sites (H1’–H5’) were calculated by using molecular dynamics (MD) simulation. The result found that the accessibility is well correlated with the site-dependent reactivity with OH radicals experimentally reported. This indicates that the DNA damage production is mainly determined by the atomistic features of accessibility. Compared with the previous study, the present MD provided a slightly improved correlation, which suggests importance of electrostatic interactions and DNA conformational fluctuation.","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線化学会"}]},"item_10004_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://radiation-chemistry.org/journal/","subitem_relation_type_select":"URI"}}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2188-0115","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"米谷, 佳晃"}],"nameIdentifiers":[{"nameIdentifier":"1009264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshiteru, Yonetani","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1009265","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"DNAの水和構造から放射線損傷サイトを検証する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNAの水和構造から放射線損傷サイトを検証する"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-07-30"},"publish_date":"2021-07-30","publish_status":"0","recid":"83726","relation_version_is_last":true,"title":["DNAの水和構造から放射線損傷サイトを検証する"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:08:38.074839+00:00"}