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Mouse Brain PET with a Staggered 4-Layer DOI Detector – Optimized Crystal Layer with GATE
https://repo.qst.go.jp/records/83625
https://repo.qst.go.jp/records/83625b6f3a619-41f5-4e5b-b951-d6379bb0e7d3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-15 | |||||
| タイトル | ||||||
| タイトル | Mouse Brain PET with a Staggered 4-Layer DOI Detector – Optimized Crystal Layer with GATE | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kang, Hangyu
× Kang, Hangyu× Kang, Hangyu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | For mouse brain dedicated positron emission tomography (PET), depth-of-interaction (DOI) information is necessary to provide high resolution without compromising the sensitivity. In this study, we designed mouse brain PET with a staggered 4-layer DOI detector using 1 mm crystal pitch for high-resolution molecular imaging research. The proposed PET had a 50 mm ring diameter and 11 mm axial FOV. The proof-of-concept experimental results obtained with a single DOI detector showed good crystal map quality, resolving 95% of the crystals. Based on those results, we conducted GATE simulations to optimize the crystal layer configuration which can provide the best spatial resolution throughout the field-of-view. Three different crystal layer configurations were used: (1) uniform crystal layer (5+5+5+5 mm), (2) heterogenous crystal layer (3+3+4+10 mm), and (3) heterogenous crystal layer with a total thickness of 17 mm (3+3+4+7 mm). To evaluate the spatial resolution, five cylindrical sources (D=0.1 mm, L=10 mm) with spacing of 5 mm in the radial direction were used. In addition, an ultra-micro hot phantom was used to evaluate the imaging performance. The PET images were reconstructed by using an OSEM algorithm with 8 subsets and 10 iterations. An energy window of 400-600 keV was used for the image reconstruction and sensitivity calculation. The heterogenous crystal layer configuration (3+3+4+7 mm) showed the best spatial resolution (0.45 mm at center and 0.74 mm at 10 mm radial offset) among the three. The 0.75 mm rods of the ultra-micro hot phantom could be resolved with the peak-to-valley ratio of 1.57. In conclusion, the mouse brain PET with a staggered 4-layer DOI detector using the heterogenous crystal layer configuration (3+3+4+7 mm) can provide submillimeter resolution and 1.35% sensitivity. In the future, we plan to develop a prototype mouse brain PET scanner to validate the simulation results. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2021 Virtual IEEE Nuclear Science Symposium and Medical Imaging Conference | |||||
| 発表年月日 | ||||||
| 日付 | 2021-10-22 | |||||
| 日付タイプ | Issued | |||||
