{"created":"2023-05-15T15:01:38.969025+00:00","id":83625,"links":{},"metadata":{"_buckets":{"deposit":"4aee33e2-b38d-48e2-86f1-c11a8a79b0b3"},"_deposit":{"created_by":1,"id":"83625","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83625"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083625","sets":["10:28"]},"author_link":["1007730","1007729"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-10-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"For mouse brain dedicated positron emission tomography (PET), depth-of-interaction (DOI) information is necessary to provide high resolution without compromising the sensitivity. In this study, we designed mouse brain PET with a staggered 4-layer DOI detector using 1 mm crystal pitch for high-resolution molecular imaging research. The proposed PET had a 50 mm ring diameter and 11 mm axial FOV. The proof-of-concept experimental results obtained with a single DOI detector showed good crystal map quality, resolving 95% of the crystals. Based on those results, we conducted GATE simulations to optimize the crystal layer configuration which can provide the best spatial resolution throughout the field-of-view. Three different crystal layer configurations were used: (1) uniform crystal layer (5+5+5+5 mm), (2) heterogenous crystal layer (3+3+4+10 mm), and (3) heterogenous crystal layer with a total thickness of 17 mm (3+3+4+7 mm). To evaluate the spatial resolution, five cylindrical sources (D=0.1 mm, L=10 mm) with spacing of 5 mm in the radial direction were used. In addition, an ultra-micro hot phantom was used to evaluate the imaging performance. The PET images were reconstructed by using an OSEM algorithm with 8 subsets and 10 iterations. An energy window of 400-600 keV was used for the image reconstruction and sensitivity calculation. The heterogenous crystal layer configuration (3+3+4+7 mm) showed the best spatial resolution (0.45 mm at center and 0.74 mm at 10 mm radial offset) among the three. The 0.75 mm rods of the ultra-micro hot phantom could be resolved with the peak-to-valley ratio of 1.57. In conclusion, the mouse brain PET with a staggered 4-layer DOI detector using the heterogenous crystal layer configuration (3+3+4+7 mm) can provide submillimeter resolution and 1.35% sensitivity. In the future, we plan to develop a prototype mouse brain PET scanner to validate the simulation results.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"2021 Virtual IEEE Nuclear Science Symposium and Medical Imaging Conference","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kang, Hangyu"}],"nameIdentifiers":[{"nameIdentifier":"1007729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kang, Hangyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007730","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Mouse Brain PET with a Staggered 4-Layer DOI Detector – Optimized Crystal Layer with GATE","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mouse Brain PET with a Staggered 4-Layer DOI Detector – Optimized Crystal Layer with GATE"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-15"},"publish_date":"2021-10-15","publish_status":"0","recid":"83625","relation_version_is_last":true,"title":["Mouse Brain PET with a Staggered 4-Layer DOI Detector – Optimized Crystal Layer with GATE"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:14:44.273735+00:00"}