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Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer stem cells
https://repo.qst.go.jp/records/83614
https://repo.qst.go.jp/records/836142f0f870d-98da-4eb9-8cc2-b18d01c71298
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-15 | |||||
| タイトル | ||||||
| タイトル | Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer stem cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× Lin, Xie× Zhang, Yiding× Masayuki, Hanyu× Honoka, Obata× Kotaro, Nagatsu× Hisashi, Suzuki× Zhang, Ming-Rong× Kuan, Hu× Lin, Xie× Zhang, Yiding× Masayuki, Hanyu× Honoka, Obata× Kotaro, Nagatsu× Hisashi, Suzuki× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CD133 has been recognized as a prominent biomarker for cancer stem cells (CSCs), which promote tumor relapse and metastasis. Herein, we developed a clinically relevant, stable, peptide-based positron emission tomography (PET) tracer, [64Cu]CM-2, for mapping CD133 protein in several kinds of cancers. Through the incorporation of a 6-aminohexanoic acid (Ahx) into the N-terminus of a CM peptide, we constructed a stable peptide tracer [64Cu]CM-2, which exhibited specific binding to CD133-positive CSCs in multiple preclinical tumor models. Both PET imaging and ex vivo biodistribution verified the superior performance of [64Cu]CM-2. Furthermore, the matched physical- and biological half-life of [64Cu]CM-2 makes it a state-of-art PET tracer for CD133. Therefore, [64Cu]CM-2 PET may not only enable the longitudinal tracking of CD133 dynamics in the cancer stem cell niche, but also provide a powerful and noninvasive imaging tool to track down CSCs in refractory cancers. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第4回日本核医学会分科会放射線薬品科学研究会 第20回放射性医薬品・画像診断薬研究会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-09-25 | |||||
| 日付タイプ | Issued | |||||
