{"created":"2023-05-15T15:01:38.478253+00:00","id":83614,"links":{},"metadata":{"_buckets":{"deposit":"794298ce-af53-46f6-b085-c698a2bb394b"},"_deposit":{"created_by":1,"id":"83614","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83614"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083614","sets":["10:29"]},"author_link":["1007447","1007443","1007438","1007448","1007450","1007441","1007446","1007437","1007449","1007439","1007444","1007445","1007440","1007442","1007451","1007452"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-09-25","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD133 has been recognized as a prominent biomarker for cancer stem cells (CSCs), which promote tumor relapse and metastasis. Herein, we developed a clinically relevant, stable, peptide-based positron emission tomography (PET) tracer, [64Cu]CM-2, for mapping CD133 protein in several kinds of cancers. Through the incorporation of a 6-aminohexanoic acid (Ahx) into the N-terminus of a CM peptide, we constructed a stable peptide tracer [64Cu]CM-2, which exhibited specific binding to CD133-positive CSCs in multiple preclinical tumor models. Both PET imaging and ex vivo biodistribution verified the superior performance of [64Cu]CM-2. Furthermore, the matched physical- and biological half-life of [64Cu]CM-2 makes it a state-of-art PET tracer for CD133. Therefore, [64Cu]CM-2 PET may not only enable the longitudinal tracking of CD133 dynamics in the cancer stem cell niche, but also provide a powerful and noninvasive imaging tool to track down CSCs in refractory cancers.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第4回日本核医学会分科会放射線薬品科学研究会 第20回放射性医薬品・画像診断薬研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuan, Hu"}],"nameIdentifiers":[{"nameIdentifier":"1007437","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie"}],"nameIdentifiers":[{"nameIdentifier":"1007438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding"}],"nameIdentifiers":[{"nameIdentifier":"1007439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu"}],"nameIdentifiers":[{"nameIdentifier":"1007440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honoka, Obata"}],"nameIdentifiers":[{"nameIdentifier":"1007441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu"}],"nameIdentifiers":[{"nameIdentifier":"1007442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisashi, Suzuki"}],"nameIdentifiers":[{"nameIdentifier":"1007443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1007444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honoka, Obata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kotaro, Nagatsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisashi, Suzuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007452","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer stem cells"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-09-15"},"publish_date":"2021-09-15","publish_status":"0","recid":"83614","relation_version_is_last":true,"title":["Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer stem cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:15:55.088619+00:00"}