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A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation
https://repo.qst.go.jp/records/83574
https://repo.qst.go.jp/records/83574233f39f4-263b-4982-b27f-d2d7f55540b9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-07 | |||||
| タイトル | ||||||
| タイトル | A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation | |||||
| タイトル | ||||||
| タイトル | オートファジーとG2チェックポイントのクロストークが膵がん放射線治療抵抗性に寄与している | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長谷川, 純崇
× 長谷川, 純崇× 安康, 真由香× Sumitaka, Hasegawa× Mayuka, Anko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Autophagy and cell-cycle checkpoints act in concert to confer cellular radioresistance. We investigated the functional interaction between radiation-induced autophagy and G2 checkpoint activation in highly radioresistant human pancreatic ductal adenocarcinoma (PDAC) cells. Four human PDAC cell lines (MIA PaCa-2, KP-4, Panc-1 and SUIT-2) were analyzed. Autophagy and G2/M accumulation were synchronously induced in human PDAC cells with an activated G2 checkpoint at 12 h after X-ray irradiation of 6 Gy. Radiation-induced autophagy produced the ATP levels required for cell survival. G2 checkpoint inhibitors exposure attenuated not only G2 checkpoint activation but also post-irradiation autophagy, indicating the dependence of radiation-induced autophagy on an activated G2 checkpoint. MK-1775 significantly suppressed the tumor growth of MIA PaCa-2 xenografts in combination with X-rays compared to other treatment groups to enhance the radiosensitivity of PDAC cells in vivo. A biological crosstalk exists between the G2 checkpoint activation and radiation-induced autophagy processes that are believed to independently contribute to the radioresistance of human PDAC cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第80回日本癌学会学会総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-09-30 | |||||
| 日付タイプ | Issued | |||||
