WEKO3
アイテム
{"_buckets": {"deposit": "eaa36d46-85b9-4182-91ae-8ddd5e71f242"}, "_deposit": {"created_by": 1, "id": "83574", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "83574"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00083574", "sets": ["29"]}, "author_link": ["1006963", "1006965", "1006966", "1006964"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2021-09-30", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Autophagy and cell-cycle checkpoints act in concert to confer cellular radioresistance. We investigated the functional interaction between radiation-induced autophagy and G2 checkpoint activation in highly radioresistant human pancreatic ductal adenocarcinoma (PDAC) cells. Four human PDAC cell lines (MIA PaCa-2, KP-4, Panc-1 and SUIT-2) were analyzed. Autophagy and G2/M accumulation were synchronously induced in human PDAC cells with an activated G2 checkpoint at 12 h after X-ray irradiation of 6 Gy. Radiation-induced autophagy produced the ATP levels required for cell survival. G2 checkpoint inhibitors exposure attenuated not only G2 checkpoint activation but also post-irradiation autophagy, indicating the dependence of radiation-induced autophagy on an activated G2 checkpoint. MK-1775 significantly suppressed the tumor growth of MIA PaCa-2 xenografts in combination with X-rays compared to other treatment groups to enhance the radiosensitivity of PDAC cells in vivo. A biological crosstalk exists between the G2 checkpoint activation and radiation-induced autophagy processes that are believed to independently contribute to the radioresistance of human PDAC cells.", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要(会議名, 開催地, 会期, 主催者等)", "attribute_value_mlt": [{"subitem_description": "第80回日本癌学会学会総会", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "長谷川, 純崇"}], "nameIdentifiers": [{"nameIdentifier": "1006963", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "安康, 真由香"}], "nameIdentifiers": [{"nameIdentifier": "1006964", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sumitaka, Hasegawa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1006965", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mayuka, Anko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1006966", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation"}, {"subitem_title": "オートファジーとG2チェックポイントのクロストークが膵がん放射線治療抵抗性に寄与している", "subitem_title_language": "en"}]}, "item_type_id": "10005", "owner": "1", "path": ["29"], "permalink_uri": "https://repo.qst.go.jp/records/83574", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-10-07"}, "publish_date": "2021-10-07", "publish_status": "0", "recid": "83574", "relation": {}, "relation_version_is_last": true, "title": ["A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation"], "weko_shared_id": -1}
A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation
https://repo.qst.go.jp/records/83574
https://repo.qst.go.jp/records/83574233f39f4-263b-4982-b27f-d2d7f55540b9
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-10-07 | |||||
タイトル | ||||||
タイトル | A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | オートファジーとG2チェックポイントのクロストークが膵がん放射線治療抵抗性に寄与している | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
長谷川, 純崇
× 長谷川, 純崇× 安康, 真由香× Sumitaka, Hasegawa× Mayuka, Anko |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Autophagy and cell-cycle checkpoints act in concert to confer cellular radioresistance. We investigated the functional interaction between radiation-induced autophagy and G2 checkpoint activation in highly radioresistant human pancreatic ductal adenocarcinoma (PDAC) cells. Four human PDAC cell lines (MIA PaCa-2, KP-4, Panc-1 and SUIT-2) were analyzed. Autophagy and G2/M accumulation were synchronously induced in human PDAC cells with an activated G2 checkpoint at 12 h after X-ray irradiation of 6 Gy. Radiation-induced autophagy produced the ATP levels required for cell survival. G2 checkpoint inhibitors exposure attenuated not only G2 checkpoint activation but also post-irradiation autophagy, indicating the dependence of radiation-induced autophagy on an activated G2 checkpoint. MK-1775 significantly suppressed the tumor growth of MIA PaCa-2 xenografts in combination with X-rays compared to other treatment groups to enhance the radiosensitivity of PDAC cells in vivo. A biological crosstalk exists between the G2 checkpoint activation and radiation-induced autophagy processes that are believed to independently contribute to the radioresistance of human PDAC cells. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第80回日本癌学会学会総会 | |||||
発表年月日 | ||||||
日付 | 2021-09-30 | |||||
日付タイプ | Issued |