{"created":"2023-05-15T15:01:36.681019+00:00","id":83574,"links":{},"metadata":{"_buckets":{"deposit":"eaa36d46-85b9-4182-91ae-8ddd5e71f242"},"_deposit":{"created_by":1,"id":"83574","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"83574"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00083574","sets":["10:29"]},"author_link":["1006963","1006965","1006966","1006964"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-09-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Autophagy and cell-cycle checkpoints act in concert to confer cellular radioresistance. We investigated the functional interaction between radiation-induced autophagy and G2 checkpoint activation in highly radioresistant human pancreatic ductal adenocarcinoma (PDAC) cells. Four human PDAC cell lines (MIA PaCa-2, KP-4, Panc-1 and SUIT-2) were analyzed. Autophagy and G2/M accumulation were synchronously induced in human PDAC cells with an activated G2 checkpoint at 12 h after X-ray irradiation of 6 Gy. Radiation-induced autophagy produced the ATP levels required for cell survival. G2 checkpoint inhibitors exposure attenuated not only G2 checkpoint activation but also post-irradiation autophagy, indicating the dependence of radiation-induced autophagy on an activated G2 checkpoint. MK-1775 significantly suppressed the tumor growth of MIA PaCa-2 xenografts in combination with X-rays compared to other treatment groups to enhance the radiosensitivity of PDAC cells in vivo. A biological crosstalk exists between the G2 checkpoint activation and radiation-induced autophagy processes that are believed to independently contribute to the radioresistance of human PDAC cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第80回日本癌学会学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 純崇"}],"nameIdentifiers":[{"nameIdentifier":"1006963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安康, 真由香"}],"nameIdentifiers":[{"nameIdentifier":"1006964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sumitaka, Hasegawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1006965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mayuka, Anko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1006966","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation"},{"subitem_title":"オートファジーとG2チェックポイントのクロストークが膵がん放射線治療抵抗性に寄与している","subitem_title_language":"en"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-10-07"},"publish_date":"2021-10-07","publish_status":"0","recid":"83574","relation_version_is_last":true,"title":["A mechanism of PDAC radioresistance: Crosstalk between radiation-induced autophagy and G2 checkpoint activation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:18:16.455405+00:00"}