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マウスの造血細胞におけるX線による活性酸素種の誘導の変化（Altered induction of reactive oxygen species by ex vivo X-irradiation in hematopoietic cells of C57BL/6-Tg (CAG-EGFP) mice）.
https://repo.qst.go.jp/records/83530
https://repo.qst.go.jp/records/8353052b306fb-acfd-4e46-9d25-770dd66cea54
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-05 | |||||
| タイトル | ||||||
| タイトル | マウスの造血細胞におけるX線による活性酸素種の誘導の変化（Altered induction of reactive oxygen species by ex vivo X-irradiation in hematopoietic cells of C57BL/6-Tg (CAG-EGFP) mice）. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Liu, Cuihua
× Liu, Cuihua× Hirokazu, Hirakawa× Takanori, Katsube× Fang, YaQun× Kaoru, Tanaka× Mitsuru, Nenoi× Akira, Fujimori× Bing, Wang× Liu, Cuihua× Hirokazu, Hirakawa× Takanori, Katsube× Fang, YaQun× Kaoru, Tanaka× Mitsuru, Nenoi× Akira, Fujimori× Bing, Wang |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Our previous work pointed to a critical role of excessive production of reactive oxygen species (ROS) in the increased radiation hematopoietic death in GFP transgenic mice. Meanwhile, enhanced antioxidant capability was not demonstrated in the mouse model of radiation-induced adaptive response (RAR) using rescue of radiation hematopoietic death as the endpoint. ROS induction by ex vivo X-irradiation at a dose ranging from 0.1 to 7.5 Gy in the nucleated bone marrow cells was comparatively studied using GFP transgenic and wild type (WT) mice. ROS induction was also investigated in the cells collected from mice receiving a priming dose (0.5 Gy) efficient for RAR induction in WT mice. Significantly elevated background and increased induction of ROS in the cells from GFP transgenic mice were observed compared to that from WT mice. Markedly lower background and decreased induction of ROS were observed in the cells collected from WT mice but not GFP transgenic mice, both receiving the priming dose. GFP overexpression could alter background and induction of ROS by X-irradiation in hematopoietic cells. Results provide a reasonable explanation to the previous study on the fate of cells and mice after X-irradiation, and confirm enhanced antioxidant capability in RAR. These findings also indicate that investigations involving GFP overexpression should be carefully interpreted. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第64回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-09-22 | |||||
| 日付タイプ | Issued | |||||
