@misc{oai:repo.qst.go.jp:00083530,
 author = {Liu, Cuihua and Hirokazu, Hirakawa and Takanori, Katsube and Fang, YaQun and Kaoru, Tanaka and Mitsuru, Nenoi and Akira, Fujimori and Bing, Wang and Liu, Cuihua and Hirokazu, Hirakawa and Takanori, Katsube and Fang, YaQun and Kaoru, Tanaka and Mitsuru, Nenoi and Akira, Fujimori and Bing, Wang},
 month = {Sep},
 note = {Our previous work pointed to a critical role of excessive production of reactive oxygen species (ROS) in the increased radiation hematopoietic death in GFP transgenic mice. Meanwhile, enhanced antioxidant capability was not demonstrated in the mouse model of radiation-induced adaptive response (RAR) using rescue of radiation hematopoietic death as the endpoint. ROS induction by ex vivo X-irradiation at a dose ranging from 0.1 to 7.5 Gy in the nucleated bone marrow cells was comparatively studied using GFP transgenic and wild type (WT) mice. ROS induction was also investigated in the cells collected from mice receiving a priming dose (0.5 Gy) efficient for RAR induction in WT mice. Significantly elevated background and increased induction of ROS in the cells from GFP transgenic mice were observed compared to that from WT mice. Markedly lower background and decreased induction of ROS were observed in the cells collected from WT mice but not GFP transgenic mice, both receiving the priming dose. GFP overexpression could alter background and induction of ROS by X-irradiation in hematopoietic cells. Results provide a reasonable explanation to the previous study on the fate of cells and mice after X-irradiation, and confirm enhanced antioxidant capability in RAR. These findings also indicate that investigations involving GFP overexpression should be carefully interpreted., 日本放射線影響学会第64回大会},
 title = {マウスの造血細胞におけるX線による活性酸素種の誘導の変化（Altered induction of reactive oxygen species by ex vivo X-irradiation in hematopoietic cells of C57BL/6-Tg (CAG-EGFP) mice）.},
 year = {2021}
}