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Evaluating the long-term effect of space radiation on the reproductive normality of mammalian sperm preserved on the International Space Station.
https://repo.qst.go.jp/records/83281
https://repo.qst.go.jp/records/8328142e39cd2-cd6a-42f5-97c7-f1311e59f4b8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-07-08 | |||||
| タイトル | ||||||
| タイトル | Evaluating the long-term effect of space radiation on the reproductive normality of mammalian sperm preserved on the International Space Station. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wakayama, Sayaka
× Wakayama, Sayaka× Ito, Daiyu× Kamada, Yuko× Shimazu, Toru× Suzuki, Tomomi× Nagamatsu, Aiko× Araki, Ryoko× Ishikawa, Takahiro× Kamimura, Satoshi× Hirose, Naoki× Kazama, Kousuke× Yang, Li× Inoue, Rei× Kikuchi, Yasuyuki× Hayashi, Erika× Emura, Rina× Watanabe, Ren× Nagatomo, Hiroaki× Suzuki, Hiromi× Yamamori, Tohru× N Tada, Motoki× Osada, Ikuko× Umehara, Masumi× Sano, Hiromi× Kasahara, Haruo× Higashibata, Akira× Yano, Sachiko× Abe, Masumi× Kishigami, Satoshi× Kohda, Takashi× Ooga, Masatoshi× Wakayama, Teruhiko× Ryoko, Araki× Takahiro, Ishikawa× Satoshi, Kamimura× Masumi, Abe |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Space radiation may cause DNA damage to cells and concern for the inheritance of mutations in offspring after deep space exploration. However, there is no way to study the long-term effects of space radiation using biological materials. Here, we developed a method to evaluate the biological effect of space radiation and examined the reproductive potential of mouse freeze-dried spermatozoa stored on the International Space Station (ISS) for the longest period in biological research. The space radiation did not affect sperm DNA or fertility after preservation on ISS, and many genetically normal offspring were obtained without reducing the success rate compared to the ground-preserved control. The results of ground x-ray experiments showed that sperm can be stored for more than 200 years in space. These results suggest that the effect of deep space radiation on mammalian reproduction can be evaluated using spermatozoa, even without being monitored by astronauts in Gateway. | |||||
| 書誌情報 |
Science advances 巻 7, 号 24, p. 5554, 発行日 2021-06 |
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| 出版者 | ||||||
| 出版者 | AAAS | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2375-2548 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34117068 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1126/sciadv.abg5554 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://advances.sciencemag.org/content/7/24/eabg5554 | |||||
