@article{oai:repo.qst.go.jp:00083281,
 author = {Wakayama, Sayaka and Ito, Daiyu and Kamada, Yuko and Shimazu, Toru and Suzuki, Tomomi and Nagamatsu, Aiko and Araki, Ryoko and Ishikawa, Takahiro and Kamimura, Satoshi and Hirose, Naoki and Kazama, Kousuke and Yang, Li and Inoue, Rei and Kikuchi, Yasuyuki and Hayashi, Erika and Emura, Rina and Watanabe, Ren and Nagatomo, Hiroaki and Suzuki, Hiromi and Yamamori, Tohru and N Tada, Motoki and Osada, Ikuko and Umehara, Masumi and Sano, Hiromi and Kasahara, Haruo and Higashibata, Akira and Yano, Sachiko and Abe, Masumi and Kishigami, Satoshi and Kohda, Takashi and Ooga, Masatoshi and Wakayama, Teruhiko and Ryoko, Araki and Takahiro, Ishikawa and Satoshi, Kamimura and Masumi, Abe},
 issue = {24},
 journal = {Science advances},
 month = {Jun},
 note = {Space radiation may cause DNA damage to cells and concern for the inheritance of mutations in offspring after deep space exploration. However, there is no way to study the long-term effects of space radiation using biological materials. Here, we developed a method to evaluate the biological effect of space radiation and examined the reproductive potential of mouse freeze-dried spermatozoa stored on the International Space Station (ISS) for the longest period in biological research. The space radiation did not affect sperm DNA or fertility after preservation on ISS, and many genetically normal offspring were obtained without reducing the success rate compared to the ground-preserved control. The results of ground x-ray experiments showed that sperm can be stored for more than 200 years in space. These results suggest that the effect of deep space radiation on mammalian reproduction can be evaluated using spermatozoa, even without being monitored by astronauts in Gateway.},
 title = {Evaluating the long-term effect of space radiation on the reproductive normality of mammalian sperm preserved on the International Space Station.},
 volume = {7},
 year = {2021}
}