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A total-body small animal PET scanner with a 4-layer DOI detector
https://repo.qst.go.jp/records/83032
https://repo.qst.go.jp/records/8303206cd45cd-aeb9-4626-a3b5-53d9b20b745c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-06-25 | |||||
| タイトル | ||||||
| タイトル | A total-body small animal PET scanner with a 4-layer DOI detector | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kang, Hangyu
× Kang, Hangyu× Kang, Hangyu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Development of a total-body small animal PET scanner with a 4-layer DOI detector to achieve high-sensitivity and uniform spatial resolution for rodent imaging. Methods: The proposed total-body small animal PET (TBSAP) scanner has a 53 mm inner diameter and 325.6 mm axial FOV which can cover a rat whole-body. The TBSAP consists of 6 rings each of which has 10 DOI detectors. Five out of 6 rings are used sine the detector calibration of the 5th ring has not been finished yet. Each DOI PET detector, which was originally developed for the OpenPET, consists of a 4-layer Zr-doped GSO (GSOZ) crystal array and an 8×8 array multi-anode PMT. Each crystal layer has a 16×16 array of GSOZ crystals (2.8×2.8×7.5 mm3) which yields a total crystal thickness of 30 mm. The PMT anode signals are multiplexed using a resistive network, and then digitized by the 8-bit DAQ system (Hamamatsu, Japan). The performance of the PET scanner was evaluated by using a 22Na point source (D=0.25 mm). The effects of DOI information on the radial and axial resolutions were investigated by using a Derenzo phantom. The list-mode data were reconstructed by using ordered-subset-expectation-maximization (OSEM) algorithm. Results: The measured spatial resolutions at the center and 30 mm radial offset were 1.52 mm, and 1.75 mm, respectively. The peak absolute sensitivity was 16.7% with an energy window of 400-600 keV. The 2.2 mm rods were resolved clearly in the Derenzo phantom study. The parallax errors in radial and axial directions can be effectively reduced with the 4-layer DOI information. Conclusions: The prototype total-body small animal PET scanner with a 4-layer DOI detector provides a uniform spatial resolution of 1.87± 0.19 mm across the FOV and the peak sensitivity of 16.7% at the center of the FOV. We plan to perform a real-time whole-body rat imaging using the proposed PET scanner. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Society of Nuclear Medicine and Molecular Imaging 2021 Virtual Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2021-06-11 | |||||
| 日付タイプ | Issued | |||||
