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Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making
https://repo.qst.go.jp/records/83030
https://repo.qst.go.jp/records/830303fc03011-184f-4af2-92de-8940de014063
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-06-25 | |||||
| タイトル | ||||||
| タイトル | Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kei, Oyama
× Kei, Oyama× Yukiko, Hori× Yuji, Nagai× Naohisa, Miyakawa× Koki, Mimura× Toshiyuki, Hirabayashi× Inoue, Ken-ichi× Tetsuya, Suhara× Takada, Masahiko× Makoto, Higuchi× Takafumi, Minamimoto× Kei, Oyama× Yukiko, Hori× Yuji, Nagai× Naohisa, Miyakawa× Koki, Mimura× Toshiyuki, Hirabayashi× Tetsuya, Suhara× Makoto, Higuchi× Takafumi, Minamimoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The primate prefrontal cortex (PFC) is situated at the core of higher brain functions via neural circuits such as those linking the caudate nucleus and mediodorsal thalamus. However, the distinctive roles of these prefronto-subcortical pathways remain elusive. Combining in vivo neuronal projection mapping with chemogenetic synaptic silencing, we reversibly dissected key pathways from dorsolateral part of the PFC (dlPFC) to the dorsal caudate (dCD) and lateral mediodorsal thalamus (MDl) individually in single monkeys. We found that silencing the bilateral dlPFC-MDl projections, but not the dlPFC-dCD projections, impaired performance in a spatial working memory task. Conversely, silencing the unilateral dlPFC-dCD projection, but not the unilateral dlPFC-MDl projection, altered preference in a decision-making task. These results revealed dissociable roles of the prefronto-subcortical pathways in working memory and decision-making, representing the technical advantage of imaging-guided pathway-selective chemogenetic manipulation for dissecting neural circuits underlying cognitive functions in primates. | |||||
| 書誌情報 |
Science Advances 巻 7, 号 26, p. abg4246, 発行日 2021-06 |
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| 出版者 | ||||||
| 出版者 | American Association for the Advancement of Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2375-2548 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34162548 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1126/sciadv.abg4246 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://advances.sciencemag.org/content/7/26/eabg4246 | |||||
